Title:
へリックス12指向ステロイド系医薬品
Document Type and Number:
Japanese Patent JP4866740
Kind Code:
B2
Abstract:
Compounds having the structure or their salts: are used to treat or reduce le likelihood of acquiring androgen-dependent diseases, such as prostate cancer, benign prostatic hyperplasia, polycystic ovarian syndrome, acne, hirsutism, seborrhea, androgenic alopecia and male baldness. They can be formulated together with pharmaceutically acceptable diluent or carrier or otherwise made into any pharmaceutical dosage form. Some of these compounds having tissue-specific antiandrogenic activity and tissue-specific androgenic activity can be used to treat or reduce the risk of developing diseases related to loss of androgenic stimulation. Combinations with other active pharmaceutical agents are also disclosed.
More Like This:
Inventors:
Lovely, Fernando
Thin shankers
Gothier, Sylvain
Fréchette, Yvon
Shenald, Sylvan
Bretton, rock
Thin shankers
Gothier, Sylvain
Fréchette, Yvon
Shenald, Sylvan
Bretton, rock
Application Number:
JP2006548053A
Publication Date:
February 01, 2012
Filing Date:
January 06, 2005
Export Citation:
Assignee:
ENDORECHERCHE, INC.
International Classes:
C07J31/00; A61K31/56; A61K31/565; A61K31/566; A61K31/567; A61K31/58; A61P1/14; A61P3/06; A61P3/10; A61P5/24; A61P5/26; A61P5/28; A61P7/06; A61P9/10; A61P13/08; A61P15/00; A61P15/08; A61P17/00; A61P17/02; A61P17/08; A61P17/14; A61P19/08; A61P19/10; A61P21/00; A61P35/00; A61P43/00; C07J1/00; C07J41/00; C07J43/00; C07J71/00; C07J73/00
Domestic Patent References:
| JP63035595A | ||||
| JP41018820B1 |
Foreign References:
| WO2003068217A1 |
Other References:
PAZZAGLI, M.,Preparation and evaluation of steroid chemiluminescent tracers,Journal of Steroid Biochemistry,1983年,19(1),p. 407-412
SINGH, S. M.,Androgen Receptor Antagonists (Antiandrogens): Structure-Activity Relationships,Current Medicinal Chemistry,2000年,7,p. 211-247
ISHIOKA, T.,Novel Non-Steroidal/Non-Anilide Type Androgen Antagonists with an Isoxazolone Moiety,Bioorganic & Medicinal Chemistry,2002年,10,p. 1555-1566
PERARD, S.,18-Functionalized steroids: synthesis of thioderivatives of progesterone,Steroids,1990年,55,p. 271-275
SINGH, S. M.,Androgen Receptor Antagonists (Antiandrogens): Structure-Activity Relationships,Current Medicinal Chemistry,2000年,7,p. 211-247
ISHIOKA, T.,Novel Non-Steroidal/Non-Anilide Type Androgen Antagonists with an Isoxazolone Moiety,Bioorganic & Medicinal Chemistry,2002年,10,p. 1555-1566
PERARD, S.,18-Functionalized steroids: synthesis of thioderivatives of progesterone,Steroids,1990年,55,p. 271-275
Attorney, Agent or Firm:
Kuro Fukami
Toshio Morita
Yoshihei Nakamura
Yutaka Horii
Hisato Noda
Masayuki Sakai
Toshio Morita
Yoshihei Nakamura
Yutaka Horii
Hisato Noda
Masayuki Sakai