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Title:
HETERO-BIFUNCTIONAL POLYETHYLENE GLYCOL DERIVATIVE AND METHOD FOR PREPARING IT
Document Type and Number:
Japanese Patent JP2008174755
Kind Code:
A
Abstract:

To provide a method for preparing a hetero-bifunctional derivative of poly(ethylene glycol) or a related polymer thereof with a high purity and in a high yield.

An intermediate polymer of the formula: W-poly-OH is provided with a removable group W at one terminus without going through a chromatographic purification step. The intermediate polymer W-poly-OH is first modified by converting the OH group into a first functional group X and subsequently removing W to produce a second hydroxyl group. Then, the latter hydroxyl group is converted into a second functional group Y to obtain the desired hetero-bifunctional derivative.


Inventors:
BENTLEY MICHAEL DAVID
HARRIS J MILTON
KOZLOWSKI ANTONI
Application Number:
JP2008033703A
Publication Date:
July 31, 2008
Filing Date:
February 14, 2008
Export Citation:
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Assignee:
NEKTAR THERAPEUTICS AL CORP
International Classes:
C08G65/329
Domestic Patent References:
JP2001518528A2001-10-16
JPH07316285A1995-12-05
JP2001525470A2001-12-11
JP2002500165A2002-01-08
JPH10231270A1998-09-02
JPH0748450A1995-02-21
JPH0892366A1996-04-09
JP2001518528A2001-10-16
JPH07316285A1995-12-05
JP2001525470A2001-12-11
JP2002500165A2002-01-08
JPH10231270A1998-09-02
JPH0748450A1995-02-21
JPH0892366A1996-04-09
Foreign References:
WO1999034833A11999-07-15
Attorney, Agent or Firm:
Shoichi Okuyama
Arihara Koichi
Matsushima Tetsuo



 
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