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Japanese Patent JP4432901

B2

Compounds having glucokinase activating effects and being useful as treatments for diabetes, which are represented by the following formula (I): Äwherein X<1> represents oxygen, etc., X<2> represents oxygen, etc., R<1> represents a group on Ring A such as alkylsulfonyl, etc., R<2> represents C3-7 cyclic alkyl optionally substituted with a halogen, etc., R<3> represents a substituent on Ring B such as lower alkyl, etc., formula (II): ÄChemical Formula 1Ü represents 6- to 10-membered aryl, etc., and formula (III): ÄFormula 1Ü represents monocyclic or bicyclic heteroaryl optionally having on Ring B a substituent represented by R<3> above, wherein the carbon atom of Ring B which is bonded to the nitrogen atom of the amide group of formula (I) forms a C=N bond with the nitrogen atom of the ringÜ, as well as their pharmaceutically acceptable salts.

Tomoharu Iino
Noriaki Hashimoto
Hiroshi Nakajima
Keiji Takahashi
Teruyuki Nishimura
Junichi Nagaki

JP2005502928A

March 17, 2010

February 26, 2004

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MERCK & COMPANY INCOPORATED

C07D277/20; A61K31/415; A61K31/4155; A61K31/4192; A61K31/4196; A61K31/42; A61K31/4245; A61K31/426; A61K31/427; A61K31/433; A61K31/4439; A61K31/454; A61K31/496; A61K38/04; A61K38/28; A61K45/00; A61P3/04; A61P3/10; A61P43/00; C07D213/75; C07D231/38; C07D231/40; C07D237/20; C07D239/42; C07D241/20; C07D249/04; C07D249/08; C07D261/14; C07D271/06; C07D271/07; C07D275/02; C07D275/03; C07D277/18; C07D277/46; C07D277/56; C07D277/60; C07D277/82; C07D285/06; C07D285/08; C07D285/10; C07D285/135; C07D401/12; C07D405/14; C07D413/12; C07D417/12; C07D417/14; C07D513/04; C07D285/12

JP2005525291A
JP58069812A
JP2005521646A

WO2003000267A1
WO2001044216A1
WO1997046560A1

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