Title:
複素環式カルボン酸置換基
Document Type and Number:
Japanese Patent JP2006525366
Kind Code:
A
Abstract:
The present invention relates to compounds and pharmaceutically acceptable salts of formula (I): which are useful in the treatment of metabolic disorders related to insulin resistance, leptin resistance, or hyperglycemia. Compounds of the invention include inhibitors of Protein tyrosine phosphatases, in particular Protein tyrosine phosphatase-1B (PTP-1B), that are useful in the treatment of diabetes and other PTP mediated diseases, such as cancer, neurodegenerative diseases and the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.
Inventors:
White House, Darren
Fu, Xiao Jin
Fan, Haichuan
Combs, Kelly
Juan Zand, Michael
Fu, Xiao Jin
Fan, Haichuan
Combs, Kelly
Juan Zand, Michael
Application Number:
JP2006514245A
Publication Date:
November 09, 2006
Filing Date:
April 30, 2004
Export Citation:
Assignee:
The Institute for Pharmaceutical Discovery, LRC
International Classes:
C07D207/16; A61K31/343; A61K31/381; A61K31/401; A61K31/4155; A61K31/427; A61K31/443; A61K31/4439; A61K31/496; A61K31/506; A61K31/53; A61P3/04; A61P3/06; A61P3/10; A61P5/50; A61P7/02; A61P7/04; A61P9/10; A61P9/12; A61P35/00; A61P37/02; A61P43/00; C07D307/80; C07D401/04; C07D401/14; C07D405/06; C07D405/10; C07D405/12; C07D405/14; C07D409/10; C07D417/06; C07D417/10; C07D417/12
Domestic Patent References:
| JPH05255258A | 1993-10-05 | |||
| JPH05155862A | 1993-06-22 | |||
| JP2002275168A | 2002-09-25 |
Foreign References:
| WO2002004459A1 | 2002-01-17 | |||
| WO2002004458A1 | 2002-01-17 | |||
| US6310081B1 | 2001-10-30 | |||
| DE4407488A1 | 1995-09-14 |
Attorney, Agent or Firm:
Hideto Asamura
Hajime Asamura
Naganuma Akio
Yukihiro Ikeda
Hajime Asamura
Naganuma Akio
Yukihiro Ikeda