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Title:
へテロ環化合物
Document Type and Number:
Japanese Patent JP5765342
Kind Code:
B2
Abstract:
[Problem] A novel and excellent compound which is useful as an agent for preventing and/or treating rejection reactions in various organ transplantations, allergy diseases, autoimmune diseases, and hematologic tumor, and based on a PI3K´ selective inhibitory action and/or an IL-2 production inhibitory action and/or a B cell proliferation inhibitory action (including an activation inhibitory action). [Means for Solution] The present inventors have investigated a compound having a PI3K´ selective inhibitory action and/or an IL-2 production inhibitory action and/or a B cell proliferation inhibitory action (including an activation inhibitory action), and have found that the heterocyclic compound of the present invention has a PI3K´ selective inhibitory action and/or and IL-2 production inhibitory action and/or a B cell proliferation inhibitory action (including an activation inhibitory action), thereby completing the present invention.

Inventors:
Takahashi Fumie
Imada Nao
Masahiko Shiozawa
Toru Asano
Yoshihiro Kozuki
Maeda Junko
Koji Kato
Hidehiko Fukahori
Application Number:
JP2012528686A
Publication Date:
August 19, 2015
Filing Date:
August 09, 2011
Export Citation:
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Assignee:
Astellas Pharma Inc.
International Classes:
C07D401/14; A61K31/5377; A61K31/541; A61K31/55; A61P1/04; A61P11/06; A61P17/06; A61P19/02; A61P29/00; A61P35/02; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07D403/04; C07D403/14; C07D405/14; C07D409/14; C07D413/14
Foreign References:
WO2009120094A22009-10-01
US20070244110A12007-10-18
WO2006095906A12006-09-14
WO2009093981A12009-07-30
WO2009066775A12009-05-28
WO2008032072A12008-03-20
WO2008032027A12008-03-20
WO2008032060A12008-03-20
WO2008032036A12008-03-20
WO2008032033A12008-03-20
WO2008032089A12008-03-20
WO2008032091A12008-03-20
WO2008032086A12008-03-20
WO2008032028A12008-03-20
WO2008032064A12008-03-20
WO2008032077A12008-03-20
WO2008032041A12008-03-20
WO2005095389A12005-10-13
WO2004037812A12004-05-06
WO2002088112A12002-11-07
WO2009120094A22009-10-01
US20070244110A12007-10-18
WO2006095906A12006-09-14
WO2009093981A12009-07-30
WO2009066775A12009-05-28
WO2008032072A12008-03-20
WO2008032027A12008-03-20
WO2008032060A12008-03-20
WO2008032036A12008-03-20
WO2008032033A12008-03-20
WO2008032089A12008-03-20
WO2008032091A12008-03-20
WO2008032086A12008-03-20
WO2008032028A12008-03-20
WO2008032064A12008-03-20
WO2008032077A12008-03-20
WO2008032041A12008-03-20
WO2005095389A12005-10-13
WO2004037812A12004-05-06
WO2002088112A12002-11-07
Attorney, Agent or Firm:
Morita Taku
Emiko Yano
鈴木 ▲頼▼子
Hamai Kosuke
Terakachi Terauchi
Kana Iimura
Koichiro Morihira
Kageyama Roadman
Shuya Kawahama



 
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