Title:
ＰＡＤ阻害剤としての複素環式化合物
Document Type and Number:
Japanese Patent JP7065951
Kind Code:
B2
Abstract:
Heterocyclic compounds of Formula (I), (II), and (III) are described herein along with their polymorphs, stereoisomers, prodrugs, solvates, co-crystals, intermediates, pharmaceutically acceptable salts, and metabolites thereof. The compounds described herein, their polymorphs, stereoisomers, prodrugs, solvates, co-crystals, intermediates, pharmaceutically acceptable salts, and metabolites thereof are PAD4 inhibitors and may be useful in the treatment of various disorders, for example rheumatoid arthritis, vasculitis, systemic lupus erythematosis, cutaneous lupus erythematosis, ulcerative colitis, cancer, cystic fibrosis, asthma, multiple sclerosis and psoriasis.
Inventors:
Haruru, Guru Ringappa
Duraiswamy, Atisa Yamani Jayarai
Plastic, Buki Lady
Lao, N.V.S.K.
Rayagopal, Slider Run
Duraiswamy, Atisa Yamani Jayarai
Plastic, Buki Lady
Lao, N.V.S.K.
Rayagopal, Slider Run
Application Number:
JP2020517210A
Publication Date:
May 12, 2022
Filing Date:
September 20, 2018
Export Citation:
Assignee:
Jubilanto Epipad LLC
International Classes:
C07D487/06; A61K31/4985; A61K31/5383; A61P1/02; A61P1/04; A61P3/00; A61P9/00; A61P11/00; A61P11/06; A61P13/12; A61P15/00; A61P17/02; A61P17/06; A61P19/02; A61P19/06; A61P21/00; A61P25/00; A61P29/00; A61P31/04; A61P33/00; A61P35/00; A61P37/06; A61P37/08; A61P43/00; C07D498/06
Domestic Patent References:
| JP2015522628A | ||||
| JP2006516274A |
Foreign References:
| US20100249127 | ||||
| WO2016185279A1 | ||||
| WO2017147102A1 | ||||
| WO2017042182A1 |
Other References:
RN:1893826-27-1, 1892358-83-6,DATABASE REGISTRY [ONLINE],2016年04月20日,Retrieved from STN,検索日:15 JUL 2021
Attorney, Agent or Firm:
Patent business corporation HARAKENZO WORLD PATENT & TRADEMARK
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