Title:
カスパーゼ阻害剤としての複素環ジカルバミド
Document Type and Number:
Japanese Patent JP4676676
Kind Code:
B2
Abstract:
The present invention relates to novel classes of compounds of formula I which are caspase and TNF-alpha inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting caspase and TNF-alpha activity and consequently, can be advantageously used as agents against caspase-, interleukin-1-(“IL-1”), apoptosis-, interferon-γ inducing factor-(IGIF), interferon-γ-(“IFN-γ”), or TNF-alpha mediated diseases, including inflammatory diseases, autoimmune diseases, destructive bone disorders, proliferative disorders, infectious diseases, and degenerative diseases. This invention also relates to processes for preparing the compounds of this invention. This invention also relates to methods for inhibiting caspase and TNF-alpha activity and decreasing IGIF production and IFN-γ production and methods for treating caspase-, interleukin-1, apoptosis-, and interferon-γ-, and TNF-alpha mediated diseases using the compounds and compositions of this invention.
Inventors:
Diu-Hersend, Anita
Gorec, Julian
Hersend, Serie
Knigtel, Ronald
Orchid, paul
Mirror, andrew
Mirror, karen
Martymore, michael
Webber, peter
Gorec, Julian
Hersend, Serie
Knigtel, Ronald
Orchid, paul
Mirror, andrew
Mirror, karen
Martymore, michael
Webber, peter
Application Number:
JP2002583426A
Publication Date:
April 27, 2011
Filing Date:
April 19, 2002
Export Citation:
Assignee:
VERTEX PHARMACEUTICALS INCORPORATED
International Classes:
C07D211/60; A01N1/02; A61K31/445; A61K31/4525; A61K31/4535; A61K31/454; A61K31/4545; A61K31/4725; A61P1/02; A61P1/04; A61P1/16; A61P1/18; A61P3/10; A61P5/14; A61P7/00; A61P7/06; A61P9/00; A61P9/10; A61P11/00; A61P11/02; A61P11/06; A61P13/12; A61P17/00; A61P17/02; A61P17/04; A61P17/06; A61P17/14; A61P19/00; A61P19/02; A61P19/06; A61P19/10; A61P21/00; A61P21/04; A61P25/00; A61P25/08; A61P25/14; A61P25/16; A61P25/28; A61P25/32; A61P27/02; A61P27/14; A61P29/00; A61P31/00; A61P31/04; A61P31/06; A61P31/12; A61P31/14; A61P31/18; A61P31/20; A61P35/00; A61P35/02; A61P37/00; A61P37/02; A61P37/06; A61P37/08; A61P39/02; A61P41/00; A61P43/00; C07D401/06; C07D401/10; C07D401/12; C07D405/06; C07D409/06; C07D417/06; G01N33/48
Domestic Patent References:
| JP2004509120A | ||||
| JP2001501923A |
Other References:
Methods,1999年,Vol.19,pages 121-132
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita