Title:
HETEROCYCLIC SULFIDE
Document Type and Number:
Japanese Patent JPS6452719
Kind Code:
A
Abstract:
PURPOSE: To obtain a medicine for immune stimulation, immune resurrection and cytostatic treatment, comprising a specific heterocyclic sulfide. CONSTITUTION: This medicine comprises a compound of formula I [Het is a five-membered or six-membered heterocyclic ring which may be substituted; R<1> is an alkyl, an alkenyl or a cycloalkyl in which O, S or an NR' (R' is a 1-4C alkyl) can be present in the chain or which may be substituted or a cycloalkyl which may be optionally substituted], with the proviso that a compound of formula II ((n) is 1-5) is omitted, such as 2 methylmercapto-4-methyl-1,3- thiazol-5-ylacetic acid as an active ingredient. The compound has an LD50 value larger than 1,000mg/kg in intravenous injection of mouse, 0.5-100mg/weight Kg and cytostatic amount effective for warm-blooded mammal by parenteral and oral administration and shows no toxicity in the administration.
More Like This:
Inventors:
KAARUUHAINTSU SHIYOINEMAN
BUARUTAA DEYURUKUHAIMAA
YURUGEN BURUMUBATSUHA
MIHIAERU RIMUBERUTO
HANSUUURURITSUHI SHIYORUREMAA
GEERUHARUTO DEIKUNAITE
HANSUUHAARARUTO ZETORATSUEKU
BUARUTAA DEYURUKUHAIMAA
YURUGEN BURUMUBATSUHA
MIHIAERU RIMUBERUTO
HANSUUURURITSUHI SHIYORUREMAA
GEERUHARUTO DEIKUNAITE
HANSUUHAARARUTO ZETORATSUEKU
Application Number:
JP18475288A
Publication Date:
February 28, 1989
Filing Date:
July 26, 1988
Export Citation:
Assignee:
HOECHST AG
International Classes:
A61K31/33; A61K31/41; A61K31/415; A61K31/4184; A61K31/425; A61K31/426; A61K31/428; A61K31/433; A61K31/455; A61K31/465; A61K31/53; A61P31/04; A61P35/00; A61P37/00; A61P37/04; A61P43/00; C07D211/54; C07D211/84; C07D213/80; C07D231/18; C07D235/28; C07D237/18; C07D239/38; C07D241/18; C07D249/12; C07D253/06; C07D253/07; C07D277/20; C07D277/32; C07D277/36; C07D277/46; C07D277/56; C07D277/70; C07D277/74; C07D285/125; C07D521/00; C07D285/12; (IPC1-7): A61K31/41; A61K31/415; A61K31/425; A61K31/455; A61K31/465; A61K31/53; C07D213/80; C07D231/18; C07D235/28; C07D237/18; C07D239/38; C07D241/18; C07D249/12; C07D253/06; C07D277/36; C07D277/70; C07D285/12; C07D521/00
Domestic Patent References:
| JPS60105669A | 1985-06-11 |
Foreign References:
| US3962237A | 1976-06-08 | |||
| US3629473A | 1971-12-21 | |||
| US4002624A | 1977-01-11 | |||
| US4065584A | 1977-12-27 | |||
| US3671643A | 1972-06-20 | |||
| US3907822A | 1975-09-23 | |||
| US4251527A | 1981-02-17 | |||
| EP0093908A1 | 1983-11-16 |
Attorney, Agent or Firm:
Chika Takagi (2 outside)