Title:
グルタミン酸のヘテロダイマー
Document Type and Number:
Japanese Patent JP5606737
Kind Code:
B2
Abstract:
Compounds of Formula (Ia)wherein R is a C6-C12 substituted or unsubstituted aryl, a C6-C12 substituted or unsubstituted heteroaryl, a C1-C6 substituted or unsubstituted alkyl or -NR'R',Q is C(O), O, NR', S, S(O)2, C(O)2 (CH2)pY is C(O), O, NR', S, S(O)2, C(O)2 (CH2)pZ is H or C1-C4 alkyl,R' is H, C(O), S(O)2, C(O)2, a C6-C12 substituted or unsubstituted aryl, a C6-C12 substituted or unsubstituted heteroaryl or a C1-C6 substituted or unsubstituted alkyl,when substituted, aryl, heteroaryl and alkyl are substituted with halogen, C6-C12 heteroaryl, - NR'R' or COOZ, which have diagnostic and therapeutic properties, such as the treatment and management of prostate cancer and other diseases related to NAALADase inhibition. Radiolabels can be incorporated into the structure through a variety of prosthetic groups attached at the X amino acid side chain via a carbon or hetero atom linkage.
Inventors:
Babits, John, W.
Zimmerman, Craig, N.
マレスカ, Kevin, Py.
Zimmerman, Craig, N.
マレスカ, Kevin, Py.
Application Number:
JP2009536459A
Publication Date:
October 15, 2014
Filing Date:
November 07, 2007
Export Citation:
Assignee:
Molecular Insight Fame shoe tee カルズ In condominium lei テッド
International Classes:
C07C275/16; A61K31/4402; A61K31/444; A61K47/48; A61K51/00; A61P21/02; A61P25/00; A61P25/18; A61P29/00; A61P35/00; C07C275/24; C07C275/30; C07C311/19; C07D213/38; C07B59/00; C07F1/08; C07F13/00
Attorney, Agent or Firm:
Moriaki Ogawa
Kunio Araki
Kunio Araki