Title:
ＡＦＰ抗原を認識する高親和性ＴＣＲ
Document Type and Number:
Japanese Patent JP2023518276
Kind Code:
A
Abstract:
【課題】本発明は、Ｔ細胞受容体（ＴＣＲ）および該ＴＣＲと治療剤の融合分子を提供する。【手段】該ＴＣＲはＫＷＶＥＳＩＦＬＩＦ－ＨＬＡ Ａ２４０２複合体に結合可能で結合親和性が野生型ＴＣＲの少なくとも２倍である。該融合分子は、ＫＷＶＥＳＩＦＬＩＦ－ＨＬＡ Ａ２４０２複合体を提示する腫瘍細胞を標的化する。【選択図】なし
Inventors:
Lee Yin
Peng Zhen
Chung Hongjun
Kure Mari
Peng Zhen
Chung Hongjun
Kure Mari
Application Number:
JP2022556276A
Publication Date:
April 28, 2023
Filing Date:
March 19, 2021
Export Citation:
Assignee:
X Life SC Limited
International Classes:
C12N15/12; A61K35/17; A61K38/17; A61K39/00; A61K39/395; A61P35/00; A61P37/04; C07K14/725; C12N1/15; C12N1/19; C12N1/21; C12N5/0783; C12N5/10
Foreign References:
| CN111138521A | 2020-05-12 | |||
| CN106478807A | 2017-03-08 | |||
| CN106336457A | 2017-01-18 | |||
| CN104087592A | 2014-10-08 |
Attorney, Agent or Firm:
Katsuyuki Okubo
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