Title:
高コンダクタンス型カルシウム感受性Kチャネル開口薬
Document Type and Number:
Japanese Patent JP4657917
Kind Code:
B2
Abstract:
There are disclosed a large conductance calcium-activated K channel opener comprising a compound of the formula (I): wherein ring A is a 5-membered heterocyclic ring containing any one of O, N or S, which ring may be substituted by R4, R1 is aryl, heterocyclic or heterocycle-substituted carbonyl; R2 is hydrogen, halogen, carboxy, amino, alkyl, alkoxycarbonyl, alkenyl or cycloalkyl; R3 is aryl, heterocyclic or alkyl; and R4 is hydrogen or alkyl, each of substituents may be substituted, or a pharmaceutically acceptable salt thereof as an active ingredient.
Inventors:
Toshihiro Hosaka
Kusama Mari
Kiyomi Oba
Rinoko Kono
Shuntaro Koumi
Kusama Mari
Kiyomi Oba
Rinoko Kono
Shuntaro Koumi
Application Number:
JP2005501348A
Publication Date:
March 23, 2011
Filing Date:
October 15, 2003
Export Citation:
Assignee:
Mitsubishi Tanabe Pharma Corporation
International Classes:
C07D333/24; A61K31/381; A61K31/4025; A61K31/4436; A61K31/506; A61P9/08; A61P9/10; A61P13/00; A61P13/02; A61P13/10; A61P43/00; C07D207/337; C07D307/54; C07D333/28; C07D405/04; C07D409/04; C07D409/14; C07D207/32
Domestic Patent References:
| JP2001519344A | ||||
| JP2000351773A | ||||
| JP11302270A | ||||
| JP2000516260A | ||||
| JP8225553A | ||||
| JP9278751A | ||||
| JP50013262B1 |
Foreign References:
| GB1271082B | ||||
| WO1996010567A1 | ||||
| WO1996040634A1 |
Other References:
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