Title:
ジペプチジルペプチダーゼＩ活性を評価するためのハイスループットアッセイ
Document Type and Number:
Japanese Patent JP5748664
Kind Code:
B2
Abstract:
A method of screening a compound which modulates dipeptidyl peptidase I (DPPI) activities comprises the steps of adding a peptide substrate of DPPI to a reaction mixture which comprises DPPI and a compound, wherein the peptide substrate of DPPI has at least 3 amino acids and binds to a binding site of DPPI in addition to the S1-S2 site; and measuring the molecular weight of the substrate, wherein a change in the molecular weight of the substrate is indicative of the presence of DPPI activity.
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Inventors:
Olson, Machine
Todo, Machine
Todo, Machine
Application Number:
JP2011532351A
Publication Date:
July 15, 2015
Filing Date:
October 21, 2009
Export Citation:
Assignee:
Jiyoung Son and Ji Jong Son Pharma Machinery Research and Development LLC
International Classes:
C12Q1/37; C07K7/06; C07K7/08
Foreign References:
| WO2005106012A1 | ||||
| US20020164759 | ||||
| US20070037143 | ||||
| WO2007047995A1 |
Other References:
J. Biol. Chem.,1995年,Vol. 270, No. 5,P. 2218-2223
Eur. J. Biochem.,1998年,Vol. 253,P. 300-308
Eur. J. Biochem.,1998年,Vol. 253,P. 300-308
Attorney, Agent or Firm:
Patent business corporation Odashima patent office