Title:
ヒト型化抗ＥＧＦＲ抗体可変領域の高機能性変異体
Document Type and Number:
Japanese Patent JP5818003
Kind Code:
B2
Abstract:
[Problem] Disclosed is an antibody that exhibits excellent cytotoxicity and cell growth inhibition and that is based on an anti-human epithelial cell growth factor receptor (1) (Her1) antibody (528). Further disclosed is a method for producing same, and the like. [Solution] The mutant of an H chain humanized variable region (5H) or an L chain humanized variable region (5L) of the anti-human epithelial cell growth factor receptor (1) (Her1) antibody (528) is the aforementioned antibody characterized by having one to a plurality (for example: 1 to 5, or 1 to 3) of amino acid mutations within CDR2. Further disclosed are antibody molecules containing said region, a nucleic acid molecule coding for these polypeptides, a method for producing said antibody molecules, and the like.
Inventors:
Kumagai Izumi
Takeshi Nakanishi
Ryutaro Asano
Mitsuo Umezu
Takeshi Nakanishi
Ryutaro Asano
Mitsuo Umezu
Application Number:
JP2011541902A
Publication Date:
November 18, 2015
Filing Date:
November 11, 2010
Export Citation:
Assignee:
Tohoku University
International Classes:
C07K16/28; A61K39/395; A61P35/00; C07K16/46; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12P21/08
Domestic Patent References:
| JP2004242638A | 2004-09-02 |
Foreign References:
| WO2007108152A1 | 2007-09-27 |
Other References:
JPN6015001908; Ｊ． Ｍｏｌ． Ｂｉｏｌ． Ｖｏｌ．２９１, 1999, ｐ．５８９-６０２
JPN6015001910; ＴＨＥ ＪＯＵＲＮＡＬ ＯＦ ＢＩＯＬＯＧＩＣＡＬ ＣＨＥＭＩＳＴＲＹ Ｖｏｌ．２７２， Ｎｏ．３８, 1997, ｐ．２３７７５-２３７８３
JPN6015001912; ＴＨＥ ＪＯＵＲＮＡＬ ＯＦ ＢＩＯＬＯＧＩＣＡＬ ＣＨＥＭＩＳＴＲＹ Ｖｏｌ．２８２， Ｎｏ．３８, 2007, ｐ．２７６５９-２７６６５
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JPN6015001910; ＴＨＥ ＪＯＵＲＮＡＬ ＯＦ ＢＩＯＬＯＧＩＣＡＬ ＣＨＥＭＩＳＴＲＹ Ｖｏｌ．２７２， Ｎｏ．３８, 1997, ｐ．２３７７５-２３７８３
JPN6015001912; ＴＨＥ ＪＯＵＲＮＡＬ ＯＦ ＢＩＯＬＯＧＩＣＡＬ ＣＨＥＭＩＳＴＲＹ Ｖｏｌ．２８２， Ｎｏ．３８, 2007, ｐ．２７６５９-２７６６５
JPN6015001915; Ｂｉｏｍｏｌｅｃｕｌａｒ Ｅｎｇｉｎｅｅｒｉｎｇ Ｖｏｌ．１８, 2001, ｐ．９５-１０８
Attorney, Agent or Firm:
Masahiro Abe