Title:
HISTONE ACETYLTRANSFERASE ACTIVATORS AND USES THEREOF
Document Type and Number:
Japanese Patent JP2018027960
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide compounds that bind to and modulate a histone acetyltransferase protein, where the histone acetyltransferase protein is used for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein as well as cancer.SOLUTION: There is provided a compound of formula IV, wherein X represents S, S(O), NH, O, or CH; Y represents -C(O), S(O), or NH-C(O); Rrepresents H, methyl or the like; Rrepresents H, methyl or the like; Rrepresents H, methyl, F, Cl, I, NOor CN or the like.SELECTED DRAWING: None
More Like This:
| WO/2002/100813 | MODULATORS OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS |
| JPS5859950 | PREPARATION OF DIPHENYLAMINES |
Inventors:
FENG YAN
MAURO FA
OTTAVIO ARANCIO
DENG SHIXIAN
DONALD W LANDRY
YITSHAK FRANCIS
MAURO FA
OTTAVIO ARANCIO
DENG SHIXIAN
DONALD W LANDRY
YITSHAK FRANCIS
Application Number:
JP2017176487A
Publication Date:
February 22, 2018
Filing Date:
September 14, 2017
Export Citation:
Assignee:
TRUSTEES OF COLUMBIA UNIV IN THE CITY OF NEW YORK
International Classes:
C07C233/75; A61K31/167; A61P5/38; A61P7/00; A61P7/06; A61P9/00; A61P21/02; A61P25/00; A61P25/02; A61P25/14; A61P25/16; A61P25/20; A61P25/28; A61P25/32; A61P35/00; A61P35/02; A61P43/00; C07C235/56; C07C237/40; C07C255/60; C07C275/30; C07C275/34; C07C311/17; C07C311/18; C07C317/32; C07C317/44; C07C323/37; C07C323/62; C07C323/67
Domestic Patent References:
| JPS55120513A | 1980-09-17 | |||
| JP2001151742A | 2001-06-05 |
Foreign References:
| WO2008062436A2 | 2008-05-29 | |||
| US20040235888A1 | 2004-11-25 | |||
| WO1999055663A1 | 1999-11-04 | |||
| WO2004053140A2 | 2004-06-24 | |||
| WO2005007151A1 | 2005-01-27 | |||
| DE1303920B | 1974-11-14 |
Other References:
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CHUANG, D.-M. ET AL., TRENDS IN NEUROSCIENCES, vol. 32, no. 11, JPN6018038038, 21 September 2009 (2009-09-21), pages 591 - 601, ISSN: 0003889295
伊東 恭子、他, 京府医大誌, vol. 118, no. 8, JPN7018003333, August 2009 (2009-08-01), pages 523 - 531, ISSN: 0003889296
GRAMMATICAKIS, P., C. R. ACAD. SC. PARIS, vol. 267, JPN6019030818, 1968, pages 152 - 155, ISSN: 0004092155
HUMM, A. W. ET AL., ARCHIV DER PHARMAZIE, vol. 321, JPN6019030819, 1988, pages 419 - 422, ISSN: 0004092156
Attorney, Agent or Firm:
Shinjiro Ono
Osamu Yamamoto
Toru Miyamae
Motoharu Nakanishi
Osamu Yamamoto
Toru Miyamae
Motoharu Nakanishi