Title:
HISTONE DEACETYLASE INHIBITOR
Document Type and Number:
Japanese Patent JP2013100327
Kind Code:
A
Abstract:
To provide a compound serving as a histone deacetylase inhibitor particularly useful in treating cutaneous T-cell lymphoma, neurofibromatosis, psoriasis, hair loss, skin pigmentation, and dermatitis.
The compound represented by formula (I), and a pharmaceutically acceptable salt thereof are provided. In formula (I), A comprises a functional group inhibiting histone deacetylase; L is a linker moiety; and Ar is a substituted/unsubstituted aryl/heteroaryl moiety; a substituted/unsubstituted branched/unbranched aryl aliphatic/heteroaryl aliphatic moiety; a substituted/unsubstituted cyclic/heterocyclic moiety; or a substituted/unsubstituted branched/unbranched cyclic aliphatic/heterocyclic aliphatic moiety.
Inventors:
SCHREIBER STUART L
BRADNER JAMES ELLIOT
MAZITSCHEK RALPH
BRADNER JAMES ELLIOT
MAZITSCHEK RALPH
Application Number:
JP2013008195A
Publication Date:
May 23, 2013
Filing Date:
January 21, 2013
Export Citation:
Assignee:
HARVARD COLLEGE
DANA FARBER CANCER INST INC
DANA FARBER CANCER INST INC
International Classes:
C07C259/06; A61K31/235; A61K31/422; A61P17/00; A61P17/06; A61P17/14; A61P29/00; A61P35/00; A61P43/00; C07D413/12; C07B61/00
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita