衝撃散乱を使用した気泡雲形成のために最適化されたヒストトリプシ励起シーケンス

Japanese Patent JP6977008

B2

Methods and devices for producing cavitation in tissue are provided. In one embodiment, a shock scattering method of Histotripsy therapy comprises delivering an initiation pressure waveform from an ultrasound therapy transducer into tissue, the initiation pressure waveform being configured to produce at least one bubble in the tissue, delivering a scattering pressure waveform from the ultrasound therapy transducer into the at least one bubble within a life-cycle of the at least one bubble, and producing cavitation nuclei near the at least one bubble with the scattering pressure waveform. The scattering pressure waveform can be delivered during the life-cycle of the at least one bubble. In some embodiments, the scattering pressure waveform is delivered within 5 µs to 1 s of the initiation pressure waveform. Systems for performing shock scattering Histotripsy therapy are also discussed.

Cannata, Jonathan
Hall, Timothy El
Maxwell, Adam
Theophilovic, Dejan

JP2019183193A

December 08, 2021

October 03, 2019

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Histosonics, Incorporated
Regents of the University of Michigan

A61N7/00

JP2009508649A

MAXWELL, Adam D. et al.,The Role of Compressional Pressure in the Formation of Dense Bubble Clouds in Histotripsy,In: 2009 IEEE international Ultrasonics Symposium,IEEE,2009年,pp. 81-84
MAXWELL, Adam D. et al.,Cavitation clouds created by shock scattering from bubbles during histotripsy,The Journal of the Acoustical Society of America,米国,Acoustical Society of America,2011年10月,Volume 130, Issue 4,1888-1898

Shinjiro Ono
Osamu Yamamoto
Toru Miyamae
Motoharu Nakanishi
Tatsumi Ono

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