Title:
タンパク質中空ナノ粒子とそれを用いた物質運搬体、ならびに細胞への物質導入方法
Document Type and Number:
Japanese Patent JP4085231
Kind Code:
B2
Abstract:
As a versatile means for specifically and safely transporting and transferring substances (genes, proteins, compounds, etc.) into target cells and tissues, hollow nano particles comprising a protein capable of forming particles (e.g., hepatitis B virus surface antigen protein), and a biorecognition molecule introduced therein, are provided.
Inventors:
Kuroda Shunichi
Katsuyuki Tanizawa
Masaharu Senoo
Akihiko Kondo
Ueda Masakazu
Katsuyuki Tanizawa
Masaharu Senoo
Akihiko Kondo
Ueda Masakazu
Application Number:
JP2001031308A
Publication Date:
May 14, 2008
Filing Date:
February 07, 2001
Export Citation:
Assignee:
Vehicle Co., Ltd.
International Classes:
A61K48/00; C12N15/09; A61K9/50; A61K9/51; A61K47/42; A61K47/48; A61P35/00; A61P43/00; C07K14/02; C07K19/00; C12N15/88; C12P21/02; C12R1/865
Foreign References:
| WO1998049195A1 |
Other References:
KURODA, S., et al.,Hepatitis B Virus Envelope L Protein Particles,The Journal of Biological Chemistry,1992年 1月25日,Vol.267, No.3,p.1953-1961
GOLDMANN, C., et al.,Molecular Cloning and Expression of Major Structural Protein VP1 of the Human Polyomavirus JC Virus: Formation of Virus-Like Particles Useful for Immunological and Therapeutic Studies,Journal of Virology,1999年 5月,Vol.73, No.5,p.4465-4469
MIYAMURA, K., et al.,Parvovirus particles as platforms for protein presentation,Proceedings of the National Academy of Sciences of the United States of America,米国,1994年 8月,Vol.91,p.8507-8511
LI, T-C., et al.,Expression and Self-Assembly of Empty Virus-Like Particles of Hepatitis E Virus,Journal of Virology,1997年10月,Vol.71, No.10,p.7207-7213
XING, L., et al.,Recombinant Hepatitis E Capsid Protein Self-Assembles into a Dual-Domain T = 1 Particle Presenting Native Virus Epitopes,Virology,1999年,Vol.265,p.35-45
BERTIOLI, D.J., et al.,Transgenic plants and insect cells expressing the coat protein of arabis mosaic virus produce empty virus-like particles,Journal of General Virology,1991年,Vol.72,p.1801-1809
DINGLE, K.E., et al.,Human enteric Caliciviridae: the complete genome sequence and expression of virus-like particles from a genetic group II small round structured virus,Journal of General Virology,1995年,Vol.76,p.2349-2355
MARTINEZ, C., et al.,Production of porcine parvovirus empty capsids with high immunogenic activity,Vaccine,1992年,Vol.10, Issue 10,p.684-690
CHIOU, HL., et al.,Journal of General Virology,1997年,Vol.78,p.2639-2645
GOLDMANN, C., et al.,Molecular Cloning and Expression of Major Structural Protein VP1 of the Human Polyomavirus JC Virus: Formation of Virus-Like Particles Useful for Immunological and Therapeutic Studies,Journal of Virology,1999年 5月,Vol.73, No.5,p.4465-4469
MIYAMURA, K., et al.,Parvovirus particles as platforms for protein presentation,Proceedings of the National Academy of Sciences of the United States of America,米国,1994年 8月,Vol.91,p.8507-8511
LI, T-C., et al.,Expression and Self-Assembly of Empty Virus-Like Particles of Hepatitis E Virus,Journal of Virology,1997年10月,Vol.71, No.10,p.7207-7213
XING, L., et al.,Recombinant Hepatitis E Capsid Protein Self-Assembles into a Dual-Domain T = 1 Particle Presenting Native Virus Epitopes,Virology,1999年,Vol.265,p.35-45
BERTIOLI, D.J., et al.,Transgenic plants and insect cells expressing the coat protein of arabis mosaic virus produce empty virus-like particles,Journal of General Virology,1991年,Vol.72,p.1801-1809
DINGLE, K.E., et al.,Human enteric Caliciviridae: the complete genome sequence and expression of virus-like particles from a genetic group II small round structured virus,Journal of General Virology,1995年,Vol.76,p.2349-2355
MARTINEZ, C., et al.,Production of porcine parvovirus empty capsids with high immunogenic activity,Vaccine,1992年,Vol.10, Issue 10,p.684-690
CHIOU, HL., et al.,Journal of General Virology,1997年,Vol.78,p.2639-2645
Attorney, Agent or Firm:
Eiji Saegusa
Kakehi Yuro
Kenji Saito
Kakehi Yuro
Kenji Saito