Title:
ビタミンD化合物の投与量範囲を拡大する方法
Document Type and Number:
Japanese Patent JP2006500388
Kind Code:
A
Abstract:
Inhibitors of bone calcium resorption are administered to allow high doses of vitamin D compounds or mimetics to be given with the intent of treating non-calcium related diseases such as cancer, psoriasis, and autoimmune disease without the dangers of calcification of kidney, heart, and aorta. Inhibitors of bone calcium resorption include the bis-phosphonates, OPG (osteoprotegerin) or the soluble RANKL (receptor activator of NF-kappaB ligand) receptor known as sRANK (soluble RANK which is the protein expressed by the NF-kappaB gene), and function to block the availability of calcium from bone thereby preventing hypercalcemia and the resulting calcification of soft tissues. Thus, high doses of 1alpha,25-dihydroxyvitamin D3 (1,25-(OH)2D3), its analogs, prodrugs, or mimetics can be utilized with minimal risk to a patient. Specifically, alendronate is shown to block the bone calcium mobilization activity of both 1,25-(OH)2D3 and its very potent analog, 2-methylene -19-nor-(20S)-1alpha,25-dihydroxyvitamin D3.
Inventors:
Deluca, Hector Ef
Pike, Jay Wesley
Plum, Lori Ai
Shevde, Nirpama Kay
Krugetto-Dahme, Margaret
Pike, Jay Wesley
Plum, Lori Ai
Shevde, Nirpama Kay
Krugetto-Dahme, Margaret
Application Number:
JP2004534233A
Publication Date:
January 05, 2006
Filing Date:
June 26, 2003
Export Citation:
Assignee:
WISCONSIN ALUMNI RESEARCH FOUNDATION
International Classes:
A61K31/59; A61K31/565; A61K31/593; A61K31/663; A61K45/00; A61K45/06; A61P1/04; A61P3/02; A61P3/10; A61P17/00; A61P19/08; A61P25/00; A61P35/00; A61P35/02; A61P37/06
Domestic Patent References:
| JP2003519183A | 2003-06-17 |
Foreign References:
| WO2001049295A1 | 2001-07-12 |
Attorney, Agent or Firm:
Kazuo Shamoto
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Reiko Izumiya
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Reiko Izumiya