Title:
中枢神経系の虚血または外傷の機能的回復を増大させる方法
Document Type and Number:
Japanese Patent JP4847634
Kind Code:
B2
Abstract:
The present invention provides methods and compositions for treatment of mammals afflicted with an ischemic or traumatic injury of the central nervous system. The present invention capitalizes in part upon the discovery that administration of a morphogen to such a mammal provides significant improvement in central nervous system function, even when administered after central nervous system tissue has been damaged. The methods involve the administration of dimeric proteins defined as morphogens, inducers of these morphogens, or agonists of the corresponding morphogen receptors, or implantation of cells stimulated by exposure to the morphogens. The proteins defined as morphogens comprise a structurally and functionally distinct family within the TGT- beta superfamily. Osteogenic protein-1 (OP-1) is considered to be an exemplary and preferred member of this morphogen family.
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Inventors:
Charet, Mark, F.
Finklestein, Seth, Pea.
Finklestein, Seth, Pea.
Application Number:
JP53358397A
Publication Date:
December 28, 2011
Filing Date:
March 21, 1997
Export Citation:
Assignee:
STRYKER CORPORATION
The General Hospital Corporation
The General Hospital Corporation
International Classes:
A61K38/00; A61K38/22; A61K31/00; A61K38/18; A61P25/00; C07K14/51; C07K14/52; C12N15/09; C12P21/02
Domestic Patent References:
| JP7509721A |
Foreign References:
| WO1995005846A1 |
Other References:
Neurosci Lett, 1995, Vol.187, No.1, p.21-4
Attorney, Agent or Firm:
Kiyoshi Fujino
Patent Business Corporation Moegi Patent Office
Patent Business Corporation Moegi Patent Office