Title:
タバコの煙から主要な有害オキシダントを単離する方法
Document Type and Number:
Japanese Patent JP4094545
Kind Code:
B2
Abstract:
The components of cigarette smoke, known until now, do not explain the overwhelming hazardous effects of smoking; this invention describes the isolation, identification and procedures for determination of the structure, properties and assay of a relatively stable major harmful oxidant (cs-oxidant) present in the cigarette smoke, the content of which is about 190±10 mug per cigarette; the cs-oxidant alone almost quantitatively accounts for the oxidative damage of proteins produced by the aqueous extract of whole cigarette smoke, it is also responsible for the oxidative damage of DNA; since the cs-oxidant is relatively stable, it further explains the deleterious effects of the side stream smoke and passive smoking; a number of chemical compounds/agents including vitamin C have been found to prevent the cs-oxidant induced protein oxidation in vitro.
Inventors:
Chattaji-, Indu, Busan
Application Number:
JP2003506839A
Publication Date:
June 04, 2008
Filing Date:
January 31, 2002
Export Citation:
Assignee:
Council of Scientific and Industrial Research
International Classes:
G01N30/90; A61K31/17; A61K31/194; A61K31/198; A61K31/353; A61K31/375; A61K31/4172; A61K31/52; A61K36/18; A61K38/00; A61P35/00; A61P39/02; C07C37/72; C07C37/82; C07C39/08; G01N30/06; G01N30/14; G01N30/88; G01N31/00
Domestic Patent References:
| JP51049089A | ||||
| JP58162862A |
Other References:
Koni Stone, and William A. Pryor,Analysis and Fractonation of Cigarette Tar Extracts: What Causes DNA Damage?,ACS Symposium Series 745 Natural and Selected Synthetic Toxins Biological Implications,米国,American Chemical Society,2000年,P.188-193
William A. Pryor, Koni Stone, Lun-Yi Zang, and Eliezer Bermudez,Fractionation of Aqueous Cigarette Tar Extracts: Fractions That Contain the Tar Radical Cause DNA Damege,Chemical Reseach in Toxicology,米国,American Chemical Society,1998年 4月21日,Vol.11,No.5,P.441-448
William A. Pryor, Koni Stone, Lun-Yi Zang, and Eliezer Bermudez,Fractionation of Aqueous Cigarette Tar Extracts: Fractions That Contain the Tar Radical Cause DNA Damege,Chemical Reseach in Toxicology,米国,American Chemical Society,1998年 4月21日,Vol.11,No.5,P.441-448
Attorney, Agent or Firm:
野▲崎▼ 照夫