Title:
How to create and use the piece of tissue transplantation and it which were embellished with the crosslinking agent
Document Type and Number:
Japanese Patent JP6019040
Kind Code:
B2
Abstract:
Described herein are tissue grafts derived from the placenta that possess good adhesion to biological tissues and are useful in would healing applications. In one aspect, the tissue graft includes (1) two or more layers of amnion, wherein at least one layer of amnion is cross-linked, (2) two or more layers of chorion, wherein at least one layer of amnion is cross-linked, or (3) one or more layers of amnion and chorion, wherein at least one layer of amnion and/or chorion is cross-linked. In another aspect, the grafts are composed of amnion and chorion cross-linked with one another. In a further aspect, the grafts have one or more layers sandwiched between the amnion and chorion membranes. The amnion and/or the chorion are treated with a cross-linking agent prior to the formation of the graft. The presence of the cross-linking agent present on the graft also enhances adhesion to the biological tissue of interest. Also described herein are methods for making and using the tissue grafts.
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Inventors:
Morse Brenda S.
Sys Somaly
Spencer Randle
Daniel John
Sys Somaly
Spencer Randle
Daniel John
Application Number:
JP2013553631A
Publication Date:
November 02, 2016
Filing Date:
February 13, 2012
Export Citation:
Assignee:
MIMEDX GROUP INC.
International Classes:
A61K35/50; A61L15/58; A61P17/02; A61P19/00; A61P41/00
Domestic Patent References:
| JP2006507851A | ||||
| JP2006230749A | ||||
| JP7213597A | ||||
| JP2004515451A |
Foreign References:
| US20100104539 | ||||
| WO2009033160A1 | ||||
| US20080046095 |
Attorney, Agent or Firm:
Masahiro Nanjo
Ayako Seta
Nobuhide Takei
Koichiro Inami
Ayako Seta
Nobuhide Takei
Koichiro Inami
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