落屑症候群又は落屑緑内障の発症リスクの判定方法

Japanese Patent JP7064215

B2

A method for assisting the diagnosis of the risk of developing exfoliation syndrome or exfoliation glaucoma in a subject, said method comprising: an allele measurement step of measuring alleles for at least 30 single nucleotide polymorphisms (SNPs) including the 12 core SNPs listed in Table 1 and SNPs selected from the pool SNPs listed in Table 2 (selected pool SNPs), on the basis of SNP allele information in a biological sample collected from the subject; an information acquisition step of acquiring information about the risk of developing exfoliation syndrome or exfoliation glaucoma in the subject on the basis of the results of the measurement of the alleles; and an information provision step of providing information for determining the risk of developing exfoliation syndrome or exfoliation glaucoma in the subject on the basis of the information acquired in the preceding step. According to the method of the present invention, it becomes possible to determine the presence or absence of the risk of developing exfoliation syndrome or exfoliation glaucoma in a subject and predict the degree of the aforementioned risk in the subject, by analyzing SNPs of the present invention occurring in a sample from the subject.

Kei Tashiro
Shigeru Kinoshita
Kazuhiko Mori
Yoko Ikeda
Morio Ueno
Masakazu Nakano
Kengo Yoshii

JP2018531766A

May 10, 2022

June 15, 2017

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Kyoto Prefectural University Corporation
Sysmex Corporation
Santen Pharmaceutical Co., Ltd.

C12Q1/683; C12M1/00; C12N15/09

WO2008130009A1

田代啓他,落屑症候群/落屑緑内障のゲノムワイド関連解析,第87回日本生化学会大会要旨集,2014年,2P-412,要旨全文
NAKANO Masakazu.et al.,Scientific reports,2014年06月18日,DOI: 10.1038/srep05340,p.1-6

Yoshinori Hosoda

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