Title:
骨損傷の受け易さを判定する方法
Document Type and Number:
Japanese Patent JP4174203
Kind Code:
B2
Abstract:
In one aspect, the present invention provides methods for determining susceptibility to bone damage in a subject. In some embodiments, the methods comprise screening for polymorphisms in the MTHFR and collagen Iα1 genes that are associated with susceptibility to bone damage. In some embodiments, the methods comprise screening for elevated levels of homocysteine in a subject, wherein elevated levels of homocysteine are associated with an increased risk of bone damage. The methods of the invention may be used in predicting the response of a patient to treatment. Also provided are methods for prevention or reducing the risk of bone damage in a subject.
Inventors:
Andreas Geraldus Witterlinden
Joyce beldina josepha van meurus
Joyce beldina josepha van meurus
Application Number:
JP2001341855A
Publication Date:
October 29, 2008
Filing Date:
November 07, 2001
Export Citation:
Assignee:
Oxagen Limited
International Classes:
C12N15/09; A61K31/525; A61P19/08; C07D475/04; C12Q1/68; G01N33/68
Foreign References:
| WO2000015839A1 |
Other References:
Calcif. Tissue Int., vol. 66, pp. 190-194 (2000)
N. Engl. J. Med., vol. 338, pp. 1016-1021 (1998)
Bone, vol. 26, pp. 287-290 (2000)
N. Engl. J. Med., vol. 338, pp. 1016-1021 (1998)
Bone, vol. 26, pp. 287-290 (2000)
Attorney, Agent or Firm:
Hatsushi Shimizu
Koichi Niimi
Ken Takahashi
Koichi Niimi
Ken Takahashi