Title:
細胞におけるＲＮＡ発現を増強する方法
Document Type and Number:
Japanese Patent JP7424968
Kind Code:
B2
Abstract:
The present invention describes a virus-derived factor which when provided to cells, e.g., by transfecting the cells with RNA encoding the virus-derived factor, enhances expression of RNA encoding a peptide or protein in the cells. In particular, the virus-derived factor enhances survival of cells, in particular when transfected repetitively with RNA, and reduces an IFN response of cells to transfected RNA. Accordingly, the present invention provides methods and means for enhancing expression of RNA in cells. The cells are preferably transfected with the RNA.
Inventors:
Polganov, Marco Alexander
Perkovich, Mario
Shahin, Ugur
Bezelt, Tim
Khun, Andreas
Perkovich, Mario
Shahin, Ugur
Bezelt, Tim
Khun, Andreas
Application Number:
JP2020513719A
Publication Date:
January 30, 2024
Filing Date:
September 11, 2018
Export Citation:
Assignee:
BIONTECH SE
International Classes:
C12P21/02; A61K31/7105; C12N5/071; C12N5/0783; C12N5/0784; C12N5/10
Domestic Patent References:
| JP2015534826A |
Foreign References:
| US20130309747 |
Other References:
HUMAN GENE THERAPY,2015年,vol. 26, no.11,p.751-766
Journal of Virology,2013年,vol. 87, no. 12,p. 6660-6667
Journal of Virology,2013年,vol. 87, no. 12,p. 6660-6667
Attorney, Agent or Firm:
Sonoda & Kobayashi Patent Attorneys Corporation