Title:
哺乳動物由来の検体の癌化度を評価する方法
Document Type and Number:
Japanese Patent JP5116936
Kind Code:
B2
Abstract:
The present invention relates to a method for assessing a cancerous state of a mammal-derived specimen, which comprises: (1) a first step of measuring a methylation frequency of Fibrillin2 gene contained in a mammal-derived specimen or an index value having the correlation therewith, and (2) a second ,step of determining a cancerous state of the specimen based on a difference obtained by comparing the measured methylation frequency or the index value having the correlation therewith, with a control; and the like.
Inventors:
Toshikazu Ushijima
Junji Hagiwara
Junji Hagiwara
Application Number:
JP2003322822A
Publication Date:
January 09, 2013
Filing Date:
September 16, 2003
Export Citation:
Assignee:
National Cancer Center
Sumitomo Chemical Co., Ltd.
Sumitomo Chemical Co., Ltd.
International Classes:
A61K45/00; G01N33/50; A61K48/00; A61P35/00; A61P43/00; C12N15/09; C12Q1/02; C12Q1/68; G01N33/15; G01N33/574
Other References:
医学のあゆみ, (2001), 197, [3], p.1029-1034
Proc. Natl. Acad. Sci. USA, (1997), 94, [6], p.2284-2289
Cancer Biol. Ther., (2002), 1, [3], p.293-296
Cancer Res., (2001), 61, [8], p.3225-3229
Surgery, (2001), 129, [4], p.490-497
Proc. Natl. Acad. Sci. USA, (1997), 94, [6], p.2284-2289
Cancer Biol. Ther., (2002), 1, [3], p.293-296
Cancer Res., (2001), 61, [8], p.3225-3229
Surgery, (2001), 129, [4], p.490-497
Attorney, Agent or Firm:
Toru Nakayama
Toru Sakamoto
Toru Sakamoto