Title:
シタロプラムの製造方法
Document Type and Number:
Japanese Patent JP2007511477
Kind Code:
A
Abstract:
A method for the preparation of citalopram and its pharmaceutically acceptable salts is described; it's obtained starting from 5-cyanophthalide by reaction with a mixture of 4-fluorophenyl magnesium bromide and 3-dimethylaminopropyl magnesium chloride. The intermediate obtained is showed here-below: wherein X is an halogen, preferably chlorine or bromine, which is cyclized without any isolation.
Inventors:
Kochtelli, Giovanni
Giernia, Giann Luca
Milanese, Sylvia
Giernia, Giann Luca
Milanese, Sylvia
Application Number:
JP2006537287A
Publication Date:
May 10, 2007
Filing Date:
October 22, 2004
Export Citation:
Assignee:
Eidolchem Technology Espie
International Classes:
C07D307/87; A61P25/24; C07C255/50; C07C255/58; C07F3/00; C07F3/02; A61K31/343
Domestic Patent References:
| JPS6187654A | 1986-05-06 | |||
| JP2005507900A | 2005-03-24 | |||
| JP2002530295A | 2002-09-17 | |||
| JP2002509526A | 2002-03-26 | |||
| JP2002530296A | 2002-09-17 | |||
| JPS52105162A | 1977-09-03 |
Foreign References:
| WO2002060886A1 | 2002-08-08 |
Attorney, Agent or Firm:
Mitsuo Matsui