Title:
低アレルギー性シラカバ花粉主要アレルゲンrBetv1の製造方法
Document Type and Number:
Japanese Patent JP4343702
Kind Code:
B2
Abstract:
The invention relates to a process for the preparation of hypoallergenic major birch pollen allergens by means of one or more chromatographic purification steps using essentially unbuffered aqueous bases as eluent and subsequent neutralization. The hypoallergenic major birch pollen allergens are distinguished by a lack of, but at least by reduced immunoglobulin E binding with simultaneous retention of therapeutically relevant T-cell stimulation. They can therefore be employed as low-side-effect therapeutic agents for specific immunotherapy.
Inventors:
Zuk, Roland
Fiebig, Helmut
Cromwell, Oliver
Fiebig, Helmut
Cromwell, Oliver
Application Number:
JP2003571307A
Publication Date:
October 14, 2009
Filing Date:
February 07, 2003
Export Citation:
Assignee:
Merck Patent Gesellschaft mit beschraenkter Haftung
International Classes:
C07K14/415; C12N15/09; A61K36/18; A61K39/36; A61P11/02; A61P11/06; A61P27/14; A61P37/08; C07K1/113; C07K1/36; C12P21/02; A61K38/00; A61K39/00; C12R1/19
Domestic Patent References:
| JP2004508384A |
Foreign References:
| WO1998014467A1 |
Attorney, Agent or Firm:
Kiyoji Kuzuwa