Title:
How to make multiple teeth from one isolated tooth germ
Document Type and Number:
Japanese Patent JP6342885
Kind Code:
B2
Abstract:
The object of the present invention is to provide a method for manufacturing multiple teeth from one isolated tooth germ in order to increase the absolute number of tooth germs that can be employed for transplantation. The present invention relates to a method for manufacturing a tooth. More specifically, the present invention provides a method for manufacturing multiple teeth from one isolated tooth germ comprising the epithelial and mesenchymal tissue layers characterized in that it comprises the steps of: (a) completely or partially splitting one isolated tooth germ comprising the epithelial and mesenchymal tissue layers, wherein said splitting is characterized in splitting so that each splitted tooth germ portion respectively comprises a portion of said epithelial tissue layer and a portion of said mesenchymal tissue layer, and (b) culturing said splitted tooth germs in vitro or culturing in vivo in a living animal other than humans to form multiple teeth.
Inventors:
Takashi Tsuji
Masamitsu Oshima
Masamitsu Oshima
Application Number:
JP2015500212A
Publication Date:
June 13, 2018
Filing Date:
February 07, 2014
Export Citation:
Assignee:
Organ Technologies Co., Ltd.
International Classes:
C12N5/073; C12N5/077
Other References:
Methods Mol. Biol.(Odontogenesis),2012年,vol.887,pp.149-165
PLoS ONE,2011年,vo.6, no.7,pp.e21531(1-11)
PLoS ONE,2011年,vo.6, no.7,pp.e21531(1-11)
Attorney, Agent or Firm:
Masahiro Nanjo
Ayako Seta
Koichiro Inami
Hidetoshi Hara
Ayako Seta
Koichiro Inami
Hidetoshi Hara
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