How to manufacture 2-amino substitution benzaldehyde compound

Japanese Patent JP6225358

B2

The present invention provides a method for producing a benzaldehyde in which an amino group is bonded in the 2 position, a halogeno group or an alkoxy group is bonded in the 3 position, and a hydrogen atom, an alkyl group, a halogeno group, an alkoxy group, or a cyano group is bonded independently in each of the 4, 5, and 6 positions, the method including: preparing a benzaldehyde in which a halogeno group or an alkoxy group is bonded in the 3 position, a hydrogen atom is bonded in the 2 position, and a hydrogen atom, an alkyl group, a halogeno group, an alkoxy group, or a cyano group is bonded independently in each of the 4, 5, and 6 positions so that a lithiation reaction is most active at the 2 position; acetal-protecting a formyl group in the benzaldehyde; sequentially performing lithiation, azidation, and amination of the 2 position; and the performing acetal deportection.

Shinichi Kobayashi

JP2016546566A

November 08, 2017

August 25, 2015

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Nippon Soda Co., Ltd.

C07C221/00; C07B51/00; C07C223/06

JP2003503495A
JP2013237648A

DE2306919A1
CN103030568A

REGISTRY(STN) [ONLINE],2014年5月11日(検索日:2015年11月6日)、CAS登録番号1602097-79-9
REGISTRY(STN) [ONLINE],2014年5月6日(検索日:2015年11月6日)、CAS登録番号1598290-52-8
REGISTRY(STN) [ONLINE],2008年6月8日(検索日:2015年11月6日)、CAS登録番号1026338-21-5
REGISTRY(STN) [ONLINE],2014年5月11日(検索日:2015年11月6日)、CAS登録番号1602359-03-4

Masatake Shiga
Tadashi Takahashi
Suzuki Mitsuyoshi
Yasuhiko Murayama

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