Title:
17α-アセトキシ-11β-(4-N,N-ジメチルアミノフェニル)-19-ノルプレグナ-4,9-ジエン-3,20-ジオンを得る方法
Document Type and Number:
Japanese Patent JP2006515869
Kind Code:
A
Abstract:
The process comprises (a) forming 17±-acetoxy-11²-(4-N,N-dimethylaminophenyl)-19-norpregna-4,9-diene-3,20-dione (VA-2914) isopropanol hemisolvate crystals by dissolving in isopropanol and subsequently crystallising; (b) separating the VA-2914 isopropanol hemisolvate crystals; and (c) converting said VA-2914 isopropanol hemisolvate into VA-2914. The VA-2914 compound is a steroid with anti-progestational and anti-glucocorticoid activity, useful in therapeutic and contraceptive gynaecological indications and in treating Cushing's syndrome and glaucoma.
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Inventors:
Lewis, Octavio, Silva, Kisora
Lewis, Herald, Gutierrez, Fuentes
Carlos, Rosson, Niño
Lewis, Herald, Gutierrez, Fuentes
Carlos, Rosson, Niño
Application Number:
JP2006500145A
Publication Date:
June 08, 2006
Filing Date:
January 21, 2004
Export Citation:
Assignee:
CRYSTAL PHARMA, S.A.
International Classes:
C07J7/00; C07J21/00; C07J41/00
Domestic Patent References:
| JP2002505334A | 2002-02-19 | |||
| JPH03505582A | 1991-12-05 |
Foreign References:
| WO1996030390A2 | 1996-10-03 | |||
| WO2001047945A1 | 2001-07-05 | |||
| WO2001074840A2 | 2001-10-11 |
Other References:
RAO, P. N.: "A practical large-scale synthesis of 17α-acetoxy-11β-(4-N,N-dimethylaminophenyl)-19-norpregna-4,9-", STEROIDS, vol. 65(7), JPN6010028197, 2000, pages 395 - 400, ISSN: 0001624565
Attorney, Agent or Firm:
Kenji Yoshitake
Yukitaka Nakamura
Konno Akio
Noritaka Yokota
Yukitaka Nakamura
Konno Akio
Noritaka Yokota