エストロンおよび/またはエストラジオール誘導体の調製方法

Japanese Patent JP5075629

B2

Process for the preparation of a compound of general formula (II) wherein R1 and R2 independently are hydrogen or a hydroxy- or hydrocarbyl group; or wherein R1 and R2 together are a double bonded oxygen; R3 is hydrogen; R′4 is a nitrobenzophenone group; and R5 and R6 independently are hydrogen or a hydroxy- or hydrocarbyl group; from a compound of general formula (I) wherein, R1, R2 R3, R5 and R6 are as defined above and R4 is hydrogen; wherein the compound of formula (I) is reacted under alkaline conditions with 2-chloro-5-nitrobenzophenone in the presence of an alkanolic solvent and the compound of formula (II) is directly crystallized from this alkanolic solvent. Complex of an alkanol and a compound of general formula (II) obtainable from the above process and processes wherein the above process or complex are used.

WO/1989/009058	PHARMACEUTICAL PREPARATION CONTAINING A FLUORIDE SALT
JP6106328	beta [2], alpha [3], and 5alpha-trihydroxy and Rosta 6-ON, its manufacturing method, and its use
JPS63196597	1-METHYL-15 ALPHA-(1, 2-DIALKANOYLOXYALKYL) ANDROSTA-1, 4-DIENE-3, 17-DIONE, ITS PRODUCTION AND PREPARATION TREATING DISEASE GENERATED BY ESTROGEN CONTAINING SAID COMPOUND

Willems, El-Hem
Mars, Her Ye F
Ostendorff, M

JP2007528839A

November 21, 2012

August 22, 2005

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STICHTING TOP INSTITUTE PHARMA

C07J1/00; A61K31/56; A61P35/00; A61P43/00

US3519714

J.FISHMAN,J.AMER.CHEM.SOC.,1958年 3月 5日,V80 N5,P1213-1216
L.D.ANTONACCIO,J.ORG.CHEM.,1971年,V36 N13,P1832-1835

Yuko Noda
Kawaguchi International Patent Office
Yoshio Kawaguchi
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura

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