How to prepare nicotinamide Riboside and its derivative

Title:

How to prepare nicotinamide Riboside and its derivative

Document Type and Number:

Japanese Patent JP6208352

Kind Code:

B2

Abstract:

The invention relates to methods of preparing nicotinamide riboside and derivatives thereof. In an aspect, the invention relates to a method of preparing a compound of formula (I) wherein n is 0 or 1; m is 0 or 1; Y is O or S; R 1 is selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted primary or secondary amino, and substituted or unsubstituted azido; R 2 - R 5 , which may be the same or different, are each independently selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, and substituted or unsubstituted aryl; and X - is an anion, selected from an anion of a substituted or unsubstituted carboxylic acid, a halide, a substituted or unsubstituted sulfonate, a substituted or unsubstituted phosphate, a substituted or unsubstituted sulfate, a substituted or unsubstituted carbonate, and a substituted or unsubstituted carbamate.

Inventors:

Marie Migordo
Red Pass, Philip
Klossy, Kelly
Doherty, Mark

Application Number:

JP2016530446A

Publication Date:

October 04, 2017

Filing Date:

July 24, 2014

Export Citation:

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Assignee:

The Queens University of Belfast

International Classes:

C07H19/048; B01J21/18

Foreign References:

WO2007061798A1

Other References:

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2004年,14(18),pp.4655-4658
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2002年,12(8),pp.1135-1137
JOURNAL OF AMERICAN CHEMICAL SOCIETY,2012年,134(1),pp.367-374,368頁右欄

Attorney, Agent or Firm:

Ryoichi Takaoka
Nao Oda
Akiyo Iwahori
Kaoru Takahashi

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