Title:
酸化的損傷を低減する方法
Document Type and Number:
Japanese Patent JP4931604
Kind Code:
B2
Abstract:
The invention provides a method for reducing oxidative damage in a mammal, a removed organ, or a cell in need thereof. The method comprises administering an effective amount of an aromatic cationic peptide. The aromatic cationic peptide has (a) at least one net positive charge; (b) a minimum of three amino acids; (c) a maximum of about twenty amino acids, (d) a relationship between the minimum number of net positive charges (pm) and the total number of amino acid residues (r) wherein 3 pm is the largest number that is less than or equal to r+1; (e) a relationship between the minimum number of aromatic groups (a) and the total number of net positive charges (pt) wherein 3a or 2a is the largest number that is less than or equal to pt+1, except that when a is 1, pt may also be 1; and (f) at least one tyrosine or tryptophan amino acid.
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Inventors:
Seto Hazel H
Application Number:
JP2006551350A
Publication Date:
May 16, 2012
Filing Date:
January 21, 2005
Export Citation:
Assignee:
Cornell Research Foundation Incorporated
International Classes:
A61K38/00; A61K38/08; A61P1/16; A61P3/10; A61P9/10; A61P19/02; A61P21/00; A61P25/00; A61P25/14; A61P25/16; A61P25/28; A61P29/00; A61P31/04; A61P31/12; A61P37/00; C07K5/00; C07K5/10; C07K5/107; C07K5/117; C07K7/00
Other References:
WU,D. et al.,A highly potent peptide analgesic that protects againstischemia-reperfusion-induced myocardial stunning,Am. J. Physiol. Heart Circ. Physiol.,2002年 8月,Vol.283, No.2,P.H783-H791
Attorney, Agent or Firm:
Sadao Kumakura
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Koji Hirayama
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Koji Hirayama