Title:
エンドトキシンの体外除去方法
Document Type and Number:
Japanese Patent JP4709452
Kind Code:
B2
Abstract:
This invention describes blood treating material having the capacity to selectively remove endotoxin and cytokine inducing substances from blood or plasma by extracorporeal adsorption for therapeutic septic shock treatment. The endotoxin adsorption ligands of the invention are oligopeptides synthesized from amino acids having a pk>7.2 such as arginine, lysine or histidine, using a polycondensation step such that the resultant oligopeptides exhibit a high degree of polydispersity. Also provided are methods and devices using an adsorbent having a polydisperse oligopeptide of the invention immobilized on a solid state support medium for removing endotoxin from the blood of human or animal subject.
Inventors:
Bell, Carl-Martin
Stall, marx
Beck, Werner
Stall, marx
Beck, Werner
Application Number:
JP2001526563A
Publication Date:
June 22, 2011
Filing Date:
September 26, 2000
Export Citation:
Assignee:
Gambro Diary Satoren Game Behr
International Classes:
C07K1/22; A61K35/14; G01N30/88; A61L2/00; A61P31/04; B01D61/00; B01D67/00; B01D69/14; B01J20/32; C07K1/34; C07K5/04; C07K17/00; C08G69/10; A61M1/36
Foreign References:
| WO1996038410A1 | ||||
| WO2000016897A1 |
Attorney, Agent or Firm:
Sonoda Yoshitaka
Kobayashi Yoshinori
Kobayashi Yoshinori