Title:
HIT患者をアルガトロバンを用いて治療する方法
Document Type and Number:
Japanese Patent JP2007523876
Kind Code:
A
Abstract:
This invention relates to the improved methods of use of Argatroban in heparin-induced thombocytopenia.
Inventors:
Margaret M Gardner
Marcy Jay Hursting
Elizabeth A. Turka
Catherine N. Balm-Gibonii
Marcy Jay Hursting
Elizabeth A. Turka
Catherine N. Balm-Gibonii
Application Number:
JP2006520376A
Publication Date:
August 23, 2007
Filing Date:
July 16, 2004
Export Citation:
Assignee:
SMITHKLINE BEECHAM CORPORATION
International Classes:
A61P7/02; A01N43/40; A01N43/42; A61K31/352; A61K31/445; A61K31/47; A61K38/55; A61K45/00; A61P41/00; A61P43/00; C07J9/00; C07J31/00; C07J41/00; A61K
Other References:
JPN6010061077, ＳＭＹＴＨＥ，Ｍ．Ａ． ｅｔ ａｌ, "Ｖｅｎｏｕｓ ｌｉｍｂ ｇａｎｇｒｅｎｅ ｄｕｒｉｎｇ ｏｖｅｒｌａｐｐｉｎｇ ｔｈｅｒａｐｙ ｗｉｔｈ ｗａｒｆａｒｉｎ ａｎｄ ａ ｄｉｒｅｃｔ ｔｈｒｏｍｂｉｎ ｉｎｈｉｂｉｔｏｒ ｆｏｒ ｉｍ", Ａｍ Ｊ Ｈｅｍａｔｏｌ, 2002, Ｖｏｌ．７１， Ｎｏ．１, ｐ．５０−２
JPN7010003404, ＷＡＲＫＥＮＴＩＮ，Ｔ．Ｅ．, "Ｃｕｒｒｅｎｔ ａｇｅｎｔｓ ｆｏｒ ｔｈｅ ｔｒｅａｔｍｅｎｔ ｏｆ ｐａｔｉｅｎｔｓ ｗｉｔｈ ｈｅｐａｒｉｎ−ｉｎｄｕｃｅｄ ｔｈｒｏｍｂｏｃｙｔｏｐｅｎｉａ", Ｃｕｒｒ Ｏｐｉｎ Ｐｕｌｍ Ｍｅｄ, 2002, Ｖｏｌ．８， Ｎｏ．５, ｐ．４０５−１２
JPN6010061087, ＨＵＲＳＴＩＮＧ，Ｍ．Ｊ． ｅｔ ａｌ, "Ｔｈｅ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｎｏｒｍａｌｉｚｅｄ Ｒａｔｉｏ ｄｕｒｉｎｇ ｃｏｎｃｕｒｒｅｎｔ ｗａｒｆａｒｉｎ ａｎｄ ａｒｇａｔｒｏｂａｎ ａｎｔｉｃｏａｇｕｌａｔｉｏｎ： ｄｉｆｆｅｒ", Ｃｌｉｎ Ｃｈｅｍ, 1999, Ｖｏｌ．４５， Ｎｏ．３, ｐ．４０９−１２
JPN6010061092, ＫＯＮＤＯ，Ｌ．Ｍ． ｅｔ ａｌ, "Ａｒｇａｔｒｏｂａｎ ｆｏｒ ｐｒｅｖｅｎｔｉｏｎ ａｎｄ ｔｒｅａｔｍｅｎｔ ｏｆ ｔｈｒｏｍｂｏｅｍｂｏｌｉｓｍ ｉｎ ｈｅｐａｒｉｎ−ｉｎｄｕｃｅｄ ｔｈｒｏｍｂｏｃｙｔｏｐｅｎｉａ", Ａｎｎ Ｐｈａｒｍａｃｏｔｈｅｒ, 2001, Ｖｏｌ．３５， Ｎｏ．４, ｐ．４４０−５１
JPN6010061093, ＬＡＰＯＳＡＴＡ，Ｍ． ｅｔ ａｌ, "Ｃｏｌｌｅｇｅ ｏｆ Ａｍｅｒｉｃａｎ Ｐａｔｈｏｌｏｇｉｓｔｓ Ｃｏｎｆｅｒｅｎｃｅ ＸＸＸＩ ｏｎ ｌａｂｏｒａｔｏｒｙ ｍｏｎｉｔｏｒｉｎｇ ｏｆ ａｎｔｉｃｏａｇｕｌａｎｔ ｔｈｅｒａｐｙ：", Ａｒｃｈ Ｐａｔｈｏｌ Ｌａｂ Ｍｅｄ, 1998, Ｖｏｌ．１２２， Ｎｏ．９, ｐ．７９９−８０７
JPN6010061094, ＭＡＴＳＵＯ，Ｔ． ｅｔ ａｌ, "Ａｎｔｉｃｏａｇｕｌａｎｔ ｔｈｅｒａｐｙ ｗｉｔｈ ＭＤ８０５ ｏｆ ａ ｈｅｍｏｄｉａｌｙｓｉｓ ｐａｔｉｅｎｔ ｗｉｔｈ ｈｅｐａｒｉｎ−ｉｎｄｕｃｅｄ ｔｈｒｏｍｂｏｃｙｔｏｐｅｎｉａ", Ｔｈｒｏｍｂ Ｒｅｓ, 1990, Ｖｏｌ．５８， Ｎｏ．６, ｐ．６６３−６
JPN6010061099, ＡＤＫＩＮＳ，Ｊ．Ｃ． ｅｔ ａｌ, "Ｌｅｐｉｒｕｄｉｎ： ａ ｒｅｖｉｅｗ ｏｆ ｉｔｓ ｐｏｔｅｎｔｉａｌ ｐｌａｃｅ ｉｎ ｔｈｅ ｍａｎａｇｅｍｅｎｔ ｏｆ ｔｈｒｏｍｂｏｔｉｃ ｄｉｓｏｒｄｅｒｓ", ＢｉｏＤｒｕｇｓ, 1998, Ｖｏｌ．１０， Ｎｏ．３, ｐ．２２７−５５
JPN7010003404, ＷＡＲＫＥＮＴＩＮ，Ｔ．Ｅ．, "Ｃｕｒｒｅｎｔ ａｇｅｎｔｓ ｆｏｒ ｔｈｅ ｔｒｅａｔｍｅｎｔ ｏｆ ｐａｔｉｅｎｔｓ ｗｉｔｈ ｈｅｐａｒｉｎ−ｉｎｄｕｃｅｄ ｔｈｒｏｍｂｏｃｙｔｏｐｅｎｉａ", Ｃｕｒｒ Ｏｐｉｎ Ｐｕｌｍ Ｍｅｄ, 2002, Ｖｏｌ．８， Ｎｏ．５, ｐ．４０５−１２
JPN6010061087, ＨＵＲＳＴＩＮＧ，Ｍ．Ｊ． ｅｔ ａｌ, "Ｔｈｅ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｎｏｒｍａｌｉｚｅｄ Ｒａｔｉｏ ｄｕｒｉｎｇ ｃｏｎｃｕｒｒｅｎｔ ｗａｒｆａｒｉｎ ａｎｄ ａｒｇａｔｒｏｂａｎ ａｎｔｉｃｏａｇｕｌａｔｉｏｎ： ｄｉｆｆｅｒ", Ｃｌｉｎ Ｃｈｅｍ, 1999, Ｖｏｌ．４５， Ｎｏ．３, ｐ．４０９−１２
JPN6010061092, ＫＯＮＤＯ，Ｌ．Ｍ． ｅｔ ａｌ, "Ａｒｇａｔｒｏｂａｎ ｆｏｒ ｐｒｅｖｅｎｔｉｏｎ ａｎｄ ｔｒｅａｔｍｅｎｔ ｏｆ ｔｈｒｏｍｂｏｅｍｂｏｌｉｓｍ ｉｎ ｈｅｐａｒｉｎ−ｉｎｄｕｃｅｄ ｔｈｒｏｍｂｏｃｙｔｏｐｅｎｉａ", Ａｎｎ Ｐｈａｒｍａｃｏｔｈｅｒ, 2001, Ｖｏｌ．３５， Ｎｏ．４, ｐ．４４０−５１
JPN6010061093, ＬＡＰＯＳＡＴＡ，Ｍ． ｅｔ ａｌ, "Ｃｏｌｌｅｇｅ ｏｆ Ａｍｅｒｉｃａｎ Ｐａｔｈｏｌｏｇｉｓｔｓ Ｃｏｎｆｅｒｅｎｃｅ ＸＸＸＩ ｏｎ ｌａｂｏｒａｔｏｒｙ ｍｏｎｉｔｏｒｉｎｇ ｏｆ ａｎｔｉｃｏａｇｕｌａｎｔ ｔｈｅｒａｐｙ：", Ａｒｃｈ Ｐａｔｈｏｌ Ｌａｂ Ｍｅｄ, 1998, Ｖｏｌ．１２２， Ｎｏ．９, ｐ．７９９−８０７
JPN6010061094, ＭＡＴＳＵＯ，Ｔ． ｅｔ ａｌ, "Ａｎｔｉｃｏａｇｕｌａｎｔ ｔｈｅｒａｐｙ ｗｉｔｈ ＭＤ８０５ ｏｆ ａ ｈｅｍｏｄｉａｌｙｓｉｓ ｐａｔｉｅｎｔ ｗｉｔｈ ｈｅｐａｒｉｎ−ｉｎｄｕｃｅｄ ｔｈｒｏｍｂｏｃｙｔｏｐｅｎｉａ", Ｔｈｒｏｍｂ Ｒｅｓ, 1990, Ｖｏｌ．５８， Ｎｏ．６, ｐ．６６３−６
JPN6010061099, ＡＤＫＩＮＳ，Ｊ．Ｃ． ｅｔ ａｌ, "Ｌｅｐｉｒｕｄｉｎ： ａ ｒｅｖｉｅｗ ｏｆ ｉｔｓ ｐｏｔｅｎｔｉａｌ ｐｌａｃｅ ｉｎ ｔｈｅ ｍａｎａｇｅｍｅｎｔ ｏｆ ｔｈｒｏｍｂｏｔｉｃ ｄｉｓｏｒｄｅｒｓ", ＢｉｏＤｒｕｇｓ, 1998, Ｖｏｌ．１０， Ｎｏ．３, ｐ．２２７−５５
Attorney, Agent or Firm:
Mitsuo Tanaka
Tadayuki Motoyama
Kenji Tomita
Tadayuki Motoyama
Kenji Tomita