Title:
TRX媒介性疾患を処置する方法
Document Type and Number:
Japanese Patent JP2005525345
Kind Code:
A
Abstract:
The present invention provides a novel method for treating and/or preventing thioredoxin (TRX)-mediated diseases and conditions, by administering to a subject in need of such treatment a therapeutically effective amount of a histone deacetylase (HDAC) inhibitor or a pharmaceutically acceptable salt or hydrate thereof. The HDAC inhibitor can alter the expression of a thioredoxin-binding-protein (e.g. TBP-2), which in turn can lead to an altered TRX/thioredoxin-binding-protein cellular binding interaction, resulting in an increase or decrease in the level or activity of cellular TRX, for example the expression level or reducing activity of TRX. Thus the present invention relates to the use of HDAC inhibitors in a method of preventing and/or treating a wide variety of thioredoxin (TRX)-mediated diseases and conditions, such as inflammatory diseases, allergic diseases, autoimmune diseases, diseases associated with oxidative stress or diseases characterized by cellular hyperproliferation.
Inventors:
Ricorn, Victoria M.
Marks, Paul A.
Rifkind, Richard A.
Butler, Lisa Em.
Marks, Paul A.
Rifkind, Richard A.
Butler, Lisa Em.
Application Number:
JP2003569148A
Publication Date:
August 25, 2005
Filing Date:
February 14, 2003
Export Citation:
Assignee:
SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH
International Classes:
A61K31/00; A61K31/12; A61K31/121; A61K31/16; A61K31/165; A61K31/166; A61K31/167; A61K31/18; A61K31/19; A61K31/192; A61K31/275; A61K31/336; A61K31/4045; A61K31/435; A61K31/4406; A61K38/00; A61K38/12; A61K38/15; A61K45/00; A61P1/04; A61P1/14; A61P1/16; A61P1/18; A61P3/10; A61P5/14; A61P9/00; A61P9/04; A61P9/10; A61P11/00; A61P11/02; A61P11/06; A61P13/12; A61P15/00; A61P17/00; A61P17/02; A61P17/04; A61P17/06; A61P19/00; A61P19/02; A61P19/04; A61P19/10; A61P21/00; A61P25/00; A61P25/04; A61P25/16; A61P25/28; A61P29/00; A61P31/00; A61P31/18; A61P35/00; C12N15/09; A61P35/04; A61P37/00; A61P37/02; A61P37/08; A61P39/00; A61P41/00; A61P43/00; (IPC1-7): A61K45/00; A61K31/16; A61K31/167; A61K31/18; A61K31/19; A61K31/275; A61K31/336; A61K31/4045; A61K31/435; A61K31/4406; A61K38/00; A61P1/04; A61P1/14; A61P1/16; A61P1/18; A61P3/10; A61P5/14; A61P9/00; A61P9/04; A61P9/10; A61P11/00; A61P11/02; A61P11/06; A61P13/12; A61P15/00; A61P17/00; A61P17/02; A61P17/04; A61P17/06; A61P19/00; A61P19/02; A61P19/04; A61P19/10; A61P21/00; A61P25/00; A61P25/04; A61P25/16; A61P25/28; A61P29/00; A61P31/00; A61P31/18; A61P35/00; A61P35/04; A61P37/00; A61P37/02; A61P37/08; A61P39/00; A61P41/00; A61P43/00
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita