Title:
apoEに関連する疾患を治療する方法
Document Type and Number:
Japanese Patent JP4399160
Kind Code:
B2
Abstract:
The present invention provides methods inhibiting formation of neurofibrillary tangles; and methods for treating disorders relating to apolipoprotein E (apoE) in a subject. The methods generally involve reducing the level of a carboxyl-terminal truncated form of apoE in a neuronal cell of a subject. The invention further provides isolated cells comprising a nucleic acid molecule encoding a carboxyl-terminal truncated form of apoE; and methods of screening compounds using the cells. The invention further provides compounds that inhibit an apoE cleavage enzyme, and that reduce the formation of neurofibrillary tangles in a neuronal cell. The invention further provides transgenic non-human animals that include as a transgene a nucleic acid that encodes a carboxyl-terminal truncated form of apoE; as well as methods of screening compounds using transgenic animals.
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Inventors:
Fan Yea Dong
Marley Robert W.
Marley Robert W.
Application Number:
JP2002540698A
Publication Date:
January 13, 2010
Filing Date:
November 02, 2001
Export Citation:
Assignee:
The J. David Gladstone Institutes
International Classes:
A01K67/027; C12N9/99; A61K38/55; A61K45/00; A61P9/00; A61P9/10; A61P25/28; A61P29/00; C07K5/103; C07K11/00; C07K14/775; C12N5/07; C12N5/077; C12N5/078; C12N5/0793; C12N5/10; C12N15/09; C12Q1/02; C12Q1/37; G01N33/15; G01N33/50; G01N33/53; G01N33/566; A61K38/00
Domestic Patent References:
| JP5506777A |
Foreign References:
| WO2000050042A1 |
Other References:
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Attorney, Agent or Firm:
Hatsushi Shimizu