Title:
精神遅滞、ダウン症候群、脆弱X症候群および自閉症の治療方法
Document Type and Number:
Japanese Patent JP2010510314
Kind Code:
A
Abstract:
Subjects having at least one condition selected from the group consisting of mental retardation, Down's syndrome, fragile X syndrome and autism are treated with a composition that includes gamma-am inobutyric acid agonists and/or MI muscarinic receptor antagonists. The gamma-am inobutyric acid agonist (GABA) can be a GABA(B) agonist, such as baclofen. GABA(B) agonists can be used in combination with Group I mGluR antagonists and MI muscarinic receptor antagonists in methods of treating humans.
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Inventors:
Carpenter, Randall, El.
Roberts, Kathryn
Bear, Mark, F.
Roberts, Kathryn
Bear, Mark, F.
Application Number:
JP2009538409A
Publication Date:
April 02, 2010
Filing Date:
November 21, 2007
Export Citation:
Assignee:
Seaside Therapeutics, LRC
International Classes:
A61K45/00; A61K31/197; A61K31/428; A61P25/00; A61P25/18; A61P43/00; C07C229/34
Domestic Patent References:
| JP2003506407A | 2003-02-18 | |||
| JP2005500260A | 2005-01-06 | |||
| JP2001514181A | 2001-09-11 | |||
| JP2009513672A | 2009-04-02 |
Foreign References:
| WO2005025559A1 | 2005-03-24 |
Other References:
安原昭博 他: "自閉症における脳波異常と抗けいれん剤の効果", 日本小児科学会雑誌, vol. 105, no. 3, JPN6012048651, 2001, pages 372, ISSN: 0002332357
GOLDBERG-STERN,H. ET AL: "Seizure frequency and characteristics in children with Down syndrome.", BRAIN & DEV, vol. 23, no. 6, JPN6012048652, 2001, pages 375 - 378, ISSN: 0002332358
分子精神医学, vol. 1, no. 4, JPN6012048654, 2001, pages 333 - 337, ISSN: 0002332359
GOLDBERG-STERN,H. ET AL: "Seizure frequency and characteristics in children with Down syndrome.", BRAIN & DEV, vol. 23, no. 6, JPN6012048652, 2001, pages 375 - 378, ISSN: 0002332358
分子精神医学, vol. 1, no. 4, JPN6012048654, 2001, pages 333 - 337, ISSN: 0002332359
Attorney, Agent or Firm:
Yoshinori Hosoda