Title:
How to use anti-OX40 antibody and it
Document Type and Number:
Japanese Patent JP5984810
Kind Code:
B2
Abstract:
Human antibodies, preferably recombinant human antibodies, both humanized and chimeric, which specifically bind to human OX40 are disclosed. Preferred antibodies have high affinity for OX40 receptor and activate the receptor in vitro and in vivo. The antibody can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, are useful for modulating receptor activity, e.g., in a human subject suffering from a disorder in which OX40 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies are provided, and methods of synthesizing the recombinant human antibodies, are also provided.
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Inventors:
Liu Young-Jun
Vauxui Shin
Bober laura
Naoya Tsurushita
Tso Jay. Yun
Kumar Shanker
Vauxui Shin
Bober laura
Naoya Tsurushita
Tso Jay. Yun
Kumar Shanker
Application Number:
JP2013526088A
Publication Date:
September 06, 2016
Filing Date:
August 23, 2011
Export Citation:
Assignee:
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
International Classes:
C07K16/28; A61K39/395; A61P35/00; C12N1/15; C12N1/19; C12N1/21; C12N5/00; C12N15/02; C12N15/09
Foreign References:
| WO2003106498A1 | ||||
| WO2009079335A1 |
Other References:
J. Immunother.,2006年,vol.29, no.6,p.575-85
J. Exp. Med.,2008年,vol.205, no.4,p.825-39
J. Exp. Med.,2008年,vol.205, no.4,p.825-39
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
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