Title:
HTT REPRESSORS AND USES THEREOF
Document Type and Number:
Japanese Patent JP2021007405
Kind Code:
A
Abstract:
To provide: Htt repressors; methods and compositions for use of these Htt repressors; and methods and compositions for diagnosing, preventing and/or treating Huntington's disease.SOLUTION: Provided are: a non-naturally occurring zinc finger protein that binds to an Htt gene, the zinc finger protein comprising five zinc finger domains, the zinc finger domains comprising recognition helix region sequences; a polynucleotide encoding the zinc finger protein; and a pharmaceutical composition comprising the polynucleotide.SELECTED DRAWING: Figure 8
Inventors:
STEVEN FROELICH
JEFFREY C MILLER
DAVID PASCHON
EDWARD J REBAR
BRYAN ZEITLER
STEVE H ZHANG
JEFFREY C MILLER
DAVID PASCHON
EDWARD J REBAR
BRYAN ZEITLER
STEVE H ZHANG
Application Number:
JP2020173022A
Publication Date:
January 28, 2021
Filing Date:
October 14, 2020
Export Citation:
Assignee:
SANGAMO BIOSCIENCES INC
International Classes:
C12N15/62; A61K35/76; A61K38/17; A61K48/00; A61P25/14; C07K14/00; C07K19/00; C12N5/10; C12N15/864
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto