Title:
ヒト抗ＩＬ−３３中和モノクローナル抗体
Document Type and Number:
Japanese Patent JP6548696
Kind Code:
B2
Abstract:
An object of the present invention is to provide an antibody having antagonistic effect against IL-33, in particular an isolated human anti-IL-33 neutralizing monoclonal antibody wherein amino acid sequences of framework regions are amino acid sequences that are amino acid sequences from a germline or a combination of amino acid sequences thereof,, or a fragment thereof. The epitopes for a plurality of anti-IL-33 monoclonal antibodies were identified, human anti-IL-33 neutralizing monoclonal antibodies were obtained, and the complementarity-determining regions that achieve high binding ability to IL-33 was specified by introducing mutations in the complementarity-determining regions. The identified complementarity-determining regions were used to produce a human anti-IL-33 neutralizing monoclonal antibody having framework regions comprising amino acid sequences that are amino acid sequences of a germline or a combination of amino acid sequences thereof.
Inventors:
Yasuhiro Fujino
Tsutomu Yoshikawa
Hiroshi Ochi
Tsutomu Yoshikawa
Hiroshi Ochi
Application Number:
JP2017114387A
Publication Date:
July 24, 2019
Filing Date:
June 09, 2017
Export Citation:
Assignee:
Mitsubishi Tanabe Pharma Corporation
International Classes:
C07K16/24; A61K39/395; A61P1/04; A61P1/16; A61P9/00; A61P11/00; A61P11/02; A61P11/06; A61P13/12; A61P17/00; A61P19/02; A61P27/16; A61P35/00; A61P37/02; A61P37/08; A61P43/00; C07K7/06; C07K7/08; C07K14/54; C07K16/46; C12N15/13; C12P21/08
Domestic Patent References:
| JP2007523089A | ||||
| JP2008543340A | ||||
| JP2008520684A | ||||
| JP2011526591A |
Foreign References:
| WO2012113927A1 |
Attorney, Agent or Firm:
Atsushi Aoki
Shinji Mitsuhashi
Yoichi Watanabe
Masaru Nakajima
Ryotaro Takei
Hidena Tsuda
Shinji Mitsuhashi
Yoichi Watanabe
Masaru Nakajima
Ryotaro Takei
Hidena Tsuda