Title:
HUMAN ANTIBODY DERIVED FROM IMMUNIZED XENOMOUSE
Document Type and Number:
Japanese Patent JP2008253268
Kind Code:
A
Abstract:
To provide a method for producing a human antibody which scarcely becomes immunogen in treatment of human and diagnosis in vivo.
Isolated fully human antibodies against a specific antigen can be prepared by administering the antigen to a transgenic animal which has been modified to produce such antibodies in response to antigenic challenge, but whose endogenous loci have been disabled. Various subsequent manipulations can be performed to obtain either antibodies per se or analogs thereof.
Inventors:
KUCHERLAPATI RAJU
JAKOBOVITS AYA
KLAPHOLZ SUE
BRENNER DANIEL G
CAPON DANIEL J
JAKOBOVITS AYA
KLAPHOLZ SUE
BRENNER DANIEL G
CAPON DANIEL J
Application Number:
JP2008114842A
Publication Date:
October 23, 2008
Filing Date:
April 25, 2008
Export Citation:
Assignee:
AMGEN FREMONT INC
International Classes:
C07K16/18; C12N15/09; A61K39/395; A61P1/06; A61P9/10; A61P11/00; A61P11/06; A61P13/12; A61P17/00; A61P17/06; A61P19/02; A61P25/00; A61P27/02; A61P31/04; A61P35/00; A61P37/00; A61P43/00; C07K16/00; C07K16/12; C07K16/22; C07K16/24; C07K16/28; C07K16/42; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/08; G01N33/531; A61K38/00
Attorney, Agent or Firm:
Hatsushi Shimizu
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