Title:
ヒト由来抗ハンチンチン（ＨＴＴ）抗体及びその使用
Document Type and Number:
Japanese Patent JP2017522886
Kind Code:
A
Abstract:
新規なヒト由来抗ハンチンチン（ＨＴＴ）抗体及びその生物工学誘導体、好ましくは、変異したＨＴＴ種及び／又は凝集したＨＴＴ種並びに／或いはそれらのフラグメントと結合することができる新規なヒト由来抗ハンチンチン（ＨＴＴ）抗体及びその生物工学誘導体、同様にまた、それらに関連づけられる方法が提供される。このヒト由来抗ＨＴＴ抗体及び生物工学誘導体は、ハンチントン病のＨＴＴ標的化免疫療法及びその診断のための医薬組成物及び診断組成物において使用することができる。
Inventors:
Mayer, Marcel
Grimm, Yang
Grimm, Yang
Application Number:
JP2017504353A
Publication Date:
August 17, 2017
Filing Date:
July 29, 2015
Export Citation:
Assignee:
New Limune Holding A
International Classes:
C12N15/09; A61K35/12; A61K39/395; A61K45/00; A61K48/00; A61K49/00; A61K49/16; A61K51/10; A61P25/14; C07K14/47; C07K16/18; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/08
Domestic Patent References:
| JP2010514454A | 2010-05-06 |
Foreign References:
| WO2016005547A1 | 2016-01-14 | |||
| US20030232052A1 | 2003-12-18 | |||
| WO2005052002A2 | 2005-06-09 | |||
| WO2016005545A1 | 2016-01-14 |
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KHOSHNAN, A. ET AL., TRINUCLEOTIDE REPEAT PROTOCOLS, METHODS IN MOLECULAR BIOLOGY, vol. 1010, JPN6018024764, 2013, pages 231 - 251, ISSN: 0003827411
HUANG, L. ET AL., INT. J. MOL. SCI., vol. 14, JPN6019007541, 2013, pages 19109 - 19127, ISSN: 0003990509
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IIZUKA, A. ET AL., IMMUNOLOGY LETTERS, vol. 159, JPN6020007542, 15 February 2014 (2014-02-15), pages 15 - 22, ISSN: 0004224527
KLEIN, U. ET AL., IMMUNOL. REV., vol. 162, JPN6020005578, 1998, pages 261 - 280, ISSN: 0004224528
SOUTHWELL, A.L. ET AL., J. NEUROSCI., vol. 28, no. 36, JPN6018024765, 2008, pages 9013 - 9020, ISSN: 0003827412
SOUTHWELL, A.L. ET AL., J. NEUROSCI., vol. 29, no. 43, JPN6018024766, 2009, pages 13589 - 13602, ISSN: 0003827413
COLBY, D.W. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 101, no. 51, JPN6018024767, 2004, pages 17616 - 17621, ISSN: 0003827414
BUTLER, D.C. AND MESSER, A., PLOS ONE, vol. 6, no. 12, JPN6018024768, 2011, pages 29199 - 1, ISSN: 0003827415
WOLFGANG, W.J. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 102, no. 32, JPN6018024769, 2005, pages 11563 - 11568, ISSN: 0003827416
LECERF, J.-M. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 98, no. 8, JPN6018024770, 2001, pages 4764 - 4769, ISSN: 0003827417
SHEETS, M.D. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 95, JPN6018024771, 1998, pages 6157 - 6162, ISSN: 0003827418
KHOSHNAN, A. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 99, JPN6019007544, 2002, pages 1002 - 1007, ISSN: 0003990512
MESSER, A. AND JOSHI, S.N., NEUROTHERAPEUTICS, vol. 10, JPN6019007543, 2013, pages 447 - 458, ISSN: 0003990513
Attorney, Agent or Firm:
Mikiharu Hagino