HUMAN GASTRIC CANCER ANTIGENIC GENE AND GASTRIC CANCER ANTIGENIC PROTEIN

Title:

HUMAN GASTRIC CANCER ANTIGENIC GENE AND GASTRIC CANCER ANTIGENIC PROTEIN

Document Type and Number:

Japanese Patent JP2000023673

Kind Code:

A

Abstract:

To obtain a DNA which encodes a gastric cancer antigenic protein present in human gastric cancer cells, and thereby, which is useful for a treating and preventing agent for human gastric cancer, a vaccine for treatment or prevention, or the like.

This DNA encodes (A) a protein having an amino acid sequence of formula I or (B) a protein comprising an amino acid sequence of formula I in which one or several amino acids are substituted, deleted, inserted, added or inverted, and capable of activating a cytotoxic T cell recognizing a gastric cancer antigenic protein. Further, the DNA contains preferably a base sequence consisting of at least 45-534 of the base numerical order in the base sequence of formula II, and a human gastric cancer-treating and preventing vaccine containing a recombinant virus or a recombinant bacterium having the DNA is preferably prepared.

Inventors:

KIKUCHI KOKICHI
SATO NORIYUKI
TORIGOE TOSHIHIKO
SAWARA HIROMASU
SUZUKI MANABU
HAMURO JUNJI

Application Number:

JP19785298A

Publication Date:

January 25, 2000

Filing Date:

July 13, 1998

Export Citation:

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Assignee:

AJINOMOTO KK
KIKUCHI KOKICHI

International Classes:

C12N15/09; A61K35/76; A61K38/00; A61K39/00; A61K48/00; A61P3/02; C07K7/06; C07K14/47; C07K14/82; C12N15/12; C12P21/02; C12R1/91; (IPC1-7): C12N15/09; A61K35/76; A61K38/00; A61K39/00; A61K48/00; C07K7/06; C07K14/82; C12P21/02

Attorney, Agent or Firm:

Tsutomu Toyama (2 outside)

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