HUMAN LOW-AFFINITY FCE-RECEPTOR, ITS SEPARATION, PREPARATION OF ITS RECOMBINANT AND PURIFICATION THEREOF

Title:

HUMAN LOW-AFFINITY FCE-RECEPTOR, ITS SEPARATION, PREPARATION OF ITS RECOMBINANT AND PURIFICATION THEREOF

Document Type and Number:

Japanese Patent JPS6427496

Kind Code:

A

Abstract:

PURPOSE: To prepare a human low-affinity Fc-receptor, by transforming a host organism with a vector containing a code sequence of a specific human low-affinity Fc-receptor and its glycosylated derivative.

CONSTITUTION: A proper host organism is transformed with an expression vector containing a code sequence of a recombinant DNA molecule or its degenerative derivative containing a genetic information of a human low-affinity Fc-receptor or its glycosylated derivative containing an N-terminal cytoplasma domain and C-terminal extracellular domain and having a molecular weight of about 46Kd. The objective polypeptide is separated from the produced transformant to obtain the recombinant human low-affinity Fc-receptor and its glycosylated derivative substantially free from the other human-originated proteins and containing the amino acid sequence of formula.

Inventors:

KISHIMOTO CHUZO
SUEMURA MASAKI
KIKUTANI HITOSHI
BARSUMIAN EDWARD L

Application Number:

JP20733787A

Publication Date:

January 30, 1989

Filing Date:

August 20, 1987

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Assignee:

KISHIMOTO CHUZO

International Classes:

C07K1/20; C07K1/22; C07K14/00; C07K14/54; C07K14/705; C07K16/28; C12N15/09; C12P21/02; C12Q1/68; A61K38/00; A61K39/00; C12R1/19; C12R1/865; C12R1/91; (IPC1-7): C07K13/00; C07K15/12; C07K15/14; C12N15/00; C12P21/02; C12R1/19; C12R1/865; C12R1/91

Attorney, Agent or Firm:

Minoru Nakamura

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