Title:
Fcα受容体(CD89)に対するヒトモノクローナル抗体
Document Type and Number:
Japanese Patent JP2005507635
Kind Code:
A
Abstract:
Human monoclonal antibodies which bind specifically to Fc alpha receptor (CD89), including monoclonal antibodies which react specifically to Fc receptor for IgA of human effector cells are disclosed. The binding agents, e.g., antibodies are useful for targeting human effector cells (e.g. macrophages) against a target cell (e.g. a cancer cell, an infectious agent, etc.). For this purpose, bifunctional antibodies or heteroantibodies can be constructed containing the binding region derived from an anti-Fc-alpha receptor antibody and the binding region of a target-specific antibody. Targeted effector cells can specifically lyse target cells.
Inventors:
Hudson, Debra
Van de Winken, Yang
Fan Dyke, Marx, A.
Van de Winken, Yang
Fan Dyke, Marx, A.
Application Number:
JP2002564963A
Publication Date:
March 24, 2005
Filing Date:
February 11, 2002
Export Citation:
Assignee:
MEDAREX, INC.
International Classes:
A61K39/395; A61K47/48; A61P1/04; A61P1/16; A61P3/10; A61P7/04; A61P7/06; A61P11/06; A61P13/08; A61P13/12; A61P15/00; A61P17/00; A61P17/02; A61P17/06; A61P17/14; A61P19/02; A61P19/08; A61P21/04; A61P25/00; A61P27/02; A61P27/16; A61P29/00; A61P31/00; A61P31/08; A61P31/12; A61P35/00; A61P35/02; A61P37/00; A61P37/06; A61P37/08; C07K16/28; C07K19/00; C12N5/10; C12N5/20; A01K67/027; C12N15/09; C12P21/08; C12Q1/02; G01N33/68; (IPC1-7): C12N15/09; A01K67/027; A61K39/395; A61P1/04; A61P1/16; A61P3/10; A61P7/04; A61P7/06; A61P11/06; A61P13/08; A61P13/12; A61P15/00; A61P17/00; A61P17/02; A61P17/06; A61P17/14; A61P19/02; A61P19/08; A61P21/04; A61P25/00; A61P27/02; A61P27/16; A61P29/00; A61P31/08; A61P31/12; A61P35/00; A61P35/02; A61P37/06; A61P37/08; C07K16/28; C07K19/00; C12N5/10; C12Q1/02
Attorney, Agent or Firm:
Tomimasa Konishi
Tomoko Nakamura
Tomoko Nakamura