Title:
サイトカイン、ストレス、および腫瘍性蛋白質によって活性化されるヒトプロテインキナーゼキナーゼ
Document Type and Number:
Japanese Patent JP3948571
Kind Code:
B2
Abstract:
Disclosed are human mitogen-activated (MAP) kinase kinase isoforms (MKKs). MKKs mediate unique signal transduction pathways that activate human MAP kinases p38 and JNK, which result in activation of other factors, including activating transcription factor-2 (ATF2) and c-Jun. The pathways are activated by a number of factors, including cytokines and environmental stress. Methods are provided for identifying reagents that modulate MKK function or activity and for the use of such reagents in the treatment of MKK-mediated disorders.
Inventors:
Davis Roger Jay.
Apta chassis
Rain guard joel
Delizard Benoit
Apta chassis
Rain guard joel
Delizard Benoit
Application Number:
JP53478796A
Publication Date:
July 25, 2007
Filing Date:
January 26, 1996
Export Citation:
Assignee:
Davis Roger Jay.
Rain guard joel
Apta chassis
Delizard Benoit
Rain guard joel
Apta chassis
Delizard Benoit
International Classes:
C12N15/09; G01N33/53; A61K38/45; A61P1/16; A61P9/02; A61P9/10; A61P11/00; A61P13/12; A61P17/02; A61P19/02; A61P29/00; A61P37/06; C07H21/04; C07K14/075; C07K14/47; C07K14/82; C07K16/40; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/12; C12N15/54; C12Q1/48; C12Q1/68; A61K38/00
Other References:
DE ́RIJARD B,RAINGEAUD J,BARRETT T,WU I-H,DAVIS R J,HAN J,ULEVITCH R J, Independent Human MAP Kinase Signal Transduction Pathways Defined by MEK and MKK isoforms, Science, 米国,1995年 2月 3日,Vol.267,No.5198, 682-685
Attorney, Agent or Firm:
Hatsushi Shimizu
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