HUMAN TELOMERASE CATALYTIC SUBUNIT PROMOTER

Japanese Patent JPH11253177

A

To obtain a new nucleic acid useful for a compound for diagnosing a human disease, its prognosis, treatment and treating a cancer, etc., identifying treatment, screening, etc., comprising a recombinant polynucleotide containing a human telomerase reverse transcriptase promoter.

This new recombinant polynucleotide contains at least 15 bases shown by bases 1-2440 of a base sequence of the formula and a human telomerase reverse transcriptase (hTRT) promoter sequence. This nucleic acid encodes a catalytic protein subunit of human telomerase and a polypeptide related to it. The polynucleotide and the polypeptide are effective as a compound for diagnosing a human disease, its prognosis, treatment, changing proliferation ability of cell and organism and treating diseases such as a cancer, identifying treatment, screening, etc. The nucleic acid is obtained by screening a human fibroblast genome library to identify a genome containing a hTRT RNA code sequence and binding the genome to a λ phage base or the like.

CECH THOMAS R
LINGNER JOACHIM
NAKAMURA TORU
CHAPMAN KAREN B
MORIN GREGG B
HARLEY CALVIN B
ANDREWS WILLIAM H

JP32016998A

September 21, 1999

October 15, 1998

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GERON CORP
UNIV TECHNOLOGY CORP

A01K67/027; A61K31/70; A61K31/7088; A61K35/12; A61K38/00; A61K38/45; A61K38/55; A61K39/00; A61K39/395; A61K48/00; A61P35/00; A61P43/00; C07K5/10; C07K5/107; C07K5/117; C07K7/06; C07K7/08; C07K14/47; C07K16/40; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/12; C12N15/09; C12N15/113; C12N15/12; C12N15/54; C12N15/85; C12P21/08; C12Q1/02; C12Q1/48; C12Q1/68; G01N33/15; G01N33/48; G01N33/50; G01N33/53; G01N33/566; G01N33/573; C12R1/19; C12R1/84; C12R1/91; (IPC1-7): C12N15/09; A61K31/70; A61K38/55; A61K39/395; A61K48/00; C12Q1/02; C12Q1/48; C12Q1/68; G01N33/15; G01N33/48; G01N33/50

Shusaku Yamamoto

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