Title:
HUMAN TUMOR NECROSIS FACTOR
Document Type and Number:
Japanese Patent JPH08169843
Kind Code:
A
Abstract:
PURPOSE: To obtain a medicine composition containing a tumor necrosis factor, for promoting and enhancing the regeneration of injured axons of central nerve system. CONSTITUTION: This medicine composition is obtained by properly formulating the tumor necrosis factor(TNF for short), preferably a human recombinant TNF-α with a pharmaceutically permissible carrier or excipient. The composition is effective for treating nerve disorder, acute or subacute neutral nerve disorder caused by pressure or ischemia, such as glaucoma, preischemic optic nerve disease, spinal cord disorder and disorders of optic nerve and auditory nerve and is also effective for alleviating bilateral paralysis, acroparalysis, blindness, etc., after disorder. Preferably the TNF is administered immediately after occurrence of a disorder to be treated, namely is suitable for acute disorder than chronic disorder. Effects can be enhanced, for example, by irradiating an injured site with a lowenergy He-Ne laser.
Inventors:
MISHIYARU SHIYUWARUTSU
Application Number:
JP18594091A
Publication Date:
July 02, 1996
Filing Date:
April 23, 1991
Export Citation:
Assignee:
YEDA RES & DEV
International Classes:
A61K38/19; A61K38/20; A61P9/10; A61K38/22; A61P25/00; A61P27/02; A61P27/06; A61P27/16; (IPC1-7): A61K38/22; A61K38/22
Attorney, Agent or Firm:
Akira Asamura (3 outside)