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Title:
HUMANIZED ANTI-CCR2 ANTIBODY AND METHOD FOR USING THE SAME
Document Type and Number:
Japanese Patent JP2008069150
Kind Code:
A
Abstract:

To provide an antibody or a fragment thereof safely usable as a medicine expectable of effects on inflammatory diseases.

An antibody (immunoglobulin) or a functional fragment thereof (e.g. an antigen-binding fragment) which binds to a mammalian CC-chemokine receptor-2 (also referred to as CCR2, CKR-2, MCP-1RA or MCP-1RB) or a portion of the receptor (anti-CCR2) is provided. In one embodiment, the antibody or fragment thereof has specificity for human or Rhesus monkey (Macaca mulatta) CCR2 or a portion thereof. In another embodiment, the antibody or fragment thereof blocks binding of a ligand (e.g. MCP-1, MCP-2, MCP-3 or MCP-4) to the receptor and inhibits functions associated with the binding of the ligand to the receptor (e.g. leukocyte transportation).


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Inventors:
LAROSA GREGORY J
HORVATH CHRISTOPHER
NEWMAN WALTER
JONES S TARRAN
O'BRIEN SIOBHAN
O'KEEFE THERESA
Application Number:
JP2007230849A
Publication Date:
March 27, 2008
Filing Date:
September 05, 2007
Export Citation:
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Assignee:
MILLENNIUM PHARM INC
International Classes:
C07K16/28; C12N15/09; A61K38/00; A61K39/21; A61K39/395; A61P9/00; A61P9/10; A61P19/02; A61P25/00; A61P29/00; A61P31/18; A61P37/06; A61P43/00; C07K14/715; C07K16/46; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/13; C12P21/02; C12P21/08
Domestic Patent References:
JPH114694A1999-01-12
Foreign References:
WO1997031949A11997-09-04
Attorney, Agent or Firm:
Takeshi Oshio



 
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